Nlrp3 Gene Expression in Circulating Leukocytes Declines During Healthy Aging

Abstract : Aging is often associated with elevated levels of low grade inflammation supposed to drive age-associated diseases. Here, we conducted a cross-sectional study on 58 healthy volunteers, aged from 19 to 81, to investigate the relationship between age and the expression of three inflammasome component genes (Nlrp3, Asc, Casp1), the up-stream transcription factor NFkB, and the pro-inflammatory cytokine Il-1 in leukocytes. We also assessed C-reactive protein (CRP) and IL-1 in plasma, as additional inflammatory markers. We did not find any support to the hypothesis that inflammasone activation increases with age. Expression of Asc, Casp1, NFkB and Il-1 did not vary with age, body mass index, and CRP levels. In addition, expression did not differ between males and females or between smokers and non-smokers. A notable exception was the expression of Nlrp3 which varied non-linearly with age. Specifically, Nlrp3 expression strongly declined during aging, in subjects who were between 50 and 81 years old. CRP was higher in women and increased as a function of age-corrected body mass index, while only four subjects showed detectable amount of IL-1 in plasma. Further work on larger cohorts with a longitudinal monitoring should be conducted to corroborate the finding that healthy aging is associated with a decrease in inflammasome activation.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01716061
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : vendredi 23 février 2018 - 12:20:41
Dernière modification le : lundi 18 mars 2019 - 14:50:59

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Jean-Louis Connat, Adélie Dumont, Mickael Rialland, Bruno Faivre, Gabriele Sorci. Nlrp3 Gene Expression in Circulating Leukocytes Declines During Healthy Aging. Journals of Gerontology, Series A, Oxford University Press (OUP): Policy B - Oxford Open Option D, 2018, 73, pp.1045-1049. ⟨10.1093/gerona/gly018⟩. ⟨hal-01716061⟩

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