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Analyse économique des essais cliniques internationaux en cancérologie

Abstract : In oncology, as in other fields of medicine, international multicentre clinical trials came into being so as to include a sufficient number of subjects to investigate a clinical situation. The existence of tight budgetary constraints and the desire to make the best use of the resources available have resulted in the development of economic evaluations associated with these trials, which, thanks to their level of evidence and their size, provide particularly relevant material. Nonetheless, economic evaluations alongside international clinical trials raise specific questions of methodology with regard to both the design and the analysis of the results. Indeed, the costs of goods and services consumed, the types and quantities of resources, and medical practices vary from one country to another and within an individual country. Economic data from the different countries involved must be available so as to study and to take into account this variability, and appropriate techniques for cost estimations and analysis must be implemented to aggregate the results from several countries. From a review of the literature, the aim of this work was to provide an overview of the specific methodological features of economic evaluations alongside international clinical trials: analysis of efficacy data from several countries, collection of resources and real costs, methods to establish the monetary value of resources, methods to aggregate results accounting for the trial effect.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01716070
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : vendredi 23 février 2018 - 12:27:24
Dernière modification le : mardi 17 novembre 2020 - 12:43:29

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Catherine Lejeune, Béranger Lueza, Julia Bonastre. Analyse économique des essais cliniques internationaux en cancérologie. Bulletin du Cancer, John Libbey Eurotext, 2018, 105 (2), pp.204 - 211. ⟨10.1016/j.bulcan.2017.10.027⟩. ⟨hal-01716070⟩

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