Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi; Ilio Vitale; Stuart A. Aaronson; John M. Abrams; Dieter Adam; Patrizia Agostinis; Emad S. Alnemri; Lucia Altucci; Ivano Amelio; David W. Andrews; Margherita Annicchiarico-Petruzzelli; Alexey V. Antonov; Eli Arama; Eric H. Baehrecke; Nickolai A. Barlev; Nicolas G. Bazan; Francesca Bernassola; Mathieu J. M. Bertrand; Katiuscia Bianchi; Mikhail V. Blagosklonny; Klas Blomgren; Christoph Borner; Patricia Boya; Catherine Brenner; Michelangelo Campanella; Eleonora Candi; Didac Carmona-Gutierrez; Francesco Cecconi; Francis K.-M. Chan; Navdeep S. Chandel; Emily H. Cheng; Jerry E. Chipuk; John A. Cidlowski; Aaron Ciechanover; Gerald M. Cohen; Marcus Conrad; Juan R. Cubillos-Ruiz; Peter E. Czabotar; Vincenzo D Angiolella; Ted M. Dawson; Valina L. Dawson; Vincenzo De Laurenzi; Ruggero De Maria; Klaus-Michael Debatin; Ralph J. Deberardinis; Mohanish Deshmukh; Nicola Di Daniele; Francesco Di Virgilio; Vishva M. Dixit; Scott J. Dixon; Colin S. Duckett; Brian D. Dynlacht; Wafik S. El-Deiry; John W. Elrod; Gian Maria Fimia; Simone Fulda; Ana J. García-Sáez; Abhishek D. Garg; Carmen Garrido; Evripidis Gavathiotis; Pierre Golstein; Eyal Gottlieb; Douglas R. Green; Lloyd A. Greene; Hinrich Gronemeyer; Atan Gross; Gyorgy Hajnoczky; J. Marie Hardwick; Isaac S. Harris; Michael O. Hengartner; Claudio Hetz; Hidenori Ichijo; Marja Jäättelä; Bertrand Joseph; Philipp J. Jost; Philippe P. Juin; William J. Kaiser; Michael Karin; Thomas Kaufmann; Oliver Kepp; Adi Kimchi; Richard N. Kitsis; Daniel J. Klionsky; Richard A. Knight; Sharad Kumar; Sam W. Lee; John J. Lemasters; Beth Levine; Andreas Linkermann; Stuart A. Lipton; Richard A. Lockshin; Carlos López-Otín; Scott W. Lowe; Tom Luedde; Enrico Lugli; Marion Macfarlane; Frank Madeo; Michal Malewicz; Walter Malorni; Gwenola Manic; Jean-Christophe Marine; Seamus J. Martin; Jean-Claude Martinou; Jan Paul Medema; Patrick Mehlen; Pascal Meier; Sonia Melino; Edward A. Miao; Jeffery D. Molkentin; Ute M. Moll; Cristina Muñoz-Pinedo; Shigekazu Nagata; Gabriel Nuñez; Andrew Oberst; Moshe Oren; Michael Overholtzer; Michele Pagano; Theocharis Panaretakis; Manolis Pasparakis; Josef M. Penninger; David M. Pereira; Shazib Pervaiz; Marcus E. Peter; Mauro Piacentini; Paolo Pinton; Jochen H.M. Prehn; Hamsa Puthalakath; Gabriel A. Rabinovich; Markus Rehm; Rosario Rizzuto; Cecilia M.P. Rodrigues; David C. Rubinsztein; Thomas Rudel; Kevin M. Ryan; Emre Sayan; Luca Scorrano; Feng Shao; Yufang Shi; John Silke; Hans-Uwe Simon; Antonella Sistigu; Brent R. Stockwell; Andreas Strasser; Gyorgy Szabadkai; Stephen W.G. Tait; Daolin Tang; Nektarios Tavernarakis; Andrew Thorburn; Yoshihide Tsujimoto; Boris Turk; Tom Vanden Berghe; Peter Vandenabeele; Matthew G. Vander Heiden; Andreas Villunger; Herbert W. Virgin; Karen H. Vousden; Domagoj Vucic; Erwin F. Wagner; Henning Walczak; David Wallach; Ying Wang; James A. Wells; Will Wood; Junying Yuan; Zahra Zakeri; Boris Zhivotovsky; Laurence Zitvogel; Gerry Melino; Guido Kroemer

doi:10.1038/s41418-017-0012-4

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018

Lorenzo Galluzzi ^{1, 2, 3, *} Ilio Vitale Stuart A. Aaronson John M. Abrams Dieter Adam Patrizia Agostinis Emad S. Alnemri Lucia Altucci Ivano Amelio David W. Andrews Margherita Annicchiarico-Petruzzelli Alexey V. Antonov Eli Arama Eric H. Baehrecke Nickolai A. Barlev Nicolas G. Bazan Francesca Bernassola Mathieu J. M. Bertrand Katiuscia Bianchi Mikhail V. Blagosklonny Klas Blomgren Christoph Borner Patricia Boya Catherine Brenner Michelangelo Campanella Eleonora Candi Didac Carmona-Gutierrez Francesco Cecconi Francis K.-M. Chan Navdeep S. Chandel Emily H. Cheng Jerry E. Chipuk John A. Cidlowski Aaron Ciechanover Gerald M. Cohen Marcus Conrad Juan R. Cubillos-Ruiz Peter E. Czabotar Vincenzo D Angiolella Ted M. Dawson Valina L. Dawson Vincenzo De Laurenzi Ruggero De Maria Klaus-Michael Debatin Ralph J. Deberardinis Mohanish Deshmukh Nicola Di Daniele Francesco Di Virgilio Vishva M. Dixit Scott J. Dixon Colin S. Duckett Brian D. Dynlacht Wafik S. El-Deiry John W. Elrod Gian Maria Fimia Simone Fulda Ana J. García-Sáez Abhishek D. Garg Carmen Garrido ^{4, 5} Evripidis Gavathiotis Pierre Golstein ⁶ Eyal Gottlieb Douglas R. Green Lloyd A. Greene Hinrich Gronemeyer Atan Gross Gyorgy Hajnoczky J. Marie Hardwick Isaac S. Harris Michael O. Hengartner Claudio Hetz Hidenori Ichijo Marja Jäättelä Bertrand Joseph Philipp J. Jost Philippe P. Juin ⁷ William J. Kaiser Michael Karin Thomas Kaufmann Oliver Kepp ^{8, 9} Adi Kimchi Richard N. Kitsis Daniel J. Klionsky Richard A. Knight Sharad Kumar Sam W. Lee John J. Lemasters Beth Levine Andreas Linkermann Stuart A. Lipton Richard A. Lockshin Carlos López-Otín Scott W. Lowe Tom Luedde Enrico Lugli Marion Macfarlane Frank Madeo Michal Malewicz Walter Malorni Gwenola Manic Jean-Christophe Marine Seamus J. Martin Jean-Claude Martinou Jan Paul Medema Patrick Mehlen Pascal Meier Sonia Melino Edward A. Miao Jeffery D. Molkentin Ute M. Moll Cristina Muñoz-Pinedo Shigekazu Nagata Gabriel Nuñez Andrew Oberst Moshe Oren Michael Overholtzer Michele Pagano Theocharis Panaretakis Manolis Pasparakis Josef M. Penninger David M. Pereira Shazib Pervaiz Marcus E. Peter Mauro Piacentini Paolo Pinton Jochen H.M. Prehn Hamsa Puthalakath Gabriel A. Rabinovich Markus Rehm Rosario Rizzuto Cecilia M.P. Rodrigues David C. Rubinsztein Thomas Rudel Kevin M. Ryan Emre Sayan Luca Scorrano Feng Shao Yufang Shi John Silke Hans-Uwe Simon Antonella Sistigu Brent R. Stockwell Andreas Strasser Gyorgy Szabadkai Stephen W.G. Tait Daolin Tang Nektarios Tavernarakis Andrew Thorburn Yoshihide Tsujimoto Boris Turk Tom Vanden Berghe Peter Vandenabeele Matthew G. Vander Heiden Andreas Villunger Herbert W. Virgin Karen H. Vousden Domagoj Vucic Erwin F. Wagner Henning Walczak David Wallach Ying Wang James A. Wells Will Wood Junying Yuan Zahra Zakeri Boris Zhivotovsky Laurence Zitvogel ¹⁰ Gerry Melino Guido Kroemer ^{3, 11, 12, 8, 13, 14, 9, *}

* Auteur correspondant

1 Department of Radiation Oncology (Weill Cornell Medical College)

2 Sandra and Edward Meyer Cancer Center [New-York]

3 UPD5 - Université Paris Descartes - Paris 5

4 LNC - Lipides - Nutrition - Cancer [Dijon - U1231]

5 CRLCC - CGFL - Centre Régional de Lutte contre le cancer - Centre Georges-François Leclerc

6 CIML - Centre d'Immunologie de Marseille - Luminy

7 CRCINA - Département ONCO - Equipe 8 - Stress Adaptation and Tumor Escape in breast cancer - SATE

CRCINA - Centre de recherche de Cancérologie et d'Immunologie / Nantes - Angers

8 CRC - Centre de Recherche des Cordeliers

9 Plateforme de métabolomique

Direction de la recherche [Gustave Roussy]

10 UMR 1015 - Immunologie des tumeurs et immunothérapie

11 Karolinska Institutet [Stockholm]

12 IGR - Institut Gustave Roussy

13 UPMC - Université Pierre et Marie Curie - Paris 6

14 Pôle de biologie

Abstract : Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field.

Keywords : Nomenclature on cell death Cell death pathways

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Cancer

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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01727577
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : lundi 28 octobre 2019 - 12:33:49
Dernière modification le : vendredi 1 novembre 2019 - 01:40:00

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