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Article dans une revue

Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways

Abstract : Although calorically equivalent to glucose, fructose appears to be more lipogenic, promoting dyslipidemia, fatty liver disease, cardiovascular disease, and diabetes. To better understand how fructose induces lipogenesis, we compared the effects of fructose and glucose on mammalian target of rapamycin complex 1 (mTORC1), which appeared to have both positive and negative effects on lipogenic gene expression. We found that fructose acutely and transiently suppressed mTORC1 signalingin vitroandin vivoThe constitutive activation of mTORC1 reduced hepatic lipogenic gene expression and produced hypotriglyceridemia after 1 week of fructose feeding. In contrast, glucose did not suppress mTORC1, and the constitutive activation of mTORC1 failed to suppress plasma triglycerides after 1 week of glucose feeding. Thus, these data reveal fundamental differences in the signaling pathways used by fructose and glucose to regulate lipid metabolism.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01730773
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : mardi 13 mars 2018 - 15:41:39
Dernière modification le : jeudi 20 septembre 2018 - 11:26:58

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Yue Hu, Ivana Semova, Xiaowei Sun, Hong Kang, Satyapal Chahar, et al.. Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2018, 293 (6), pp.2006 - 2014. ⟨10.1074/jbc.M117.782557⟩. ⟨hal-01730773⟩

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