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The Transplantation of ω3 PUFA-Altered Gut Microbiota of Fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders

Abstract : Altering the gut microbiome may be beneficial to the host, and it recently arose as a promising strategy to manage obesity. Here, we investigated the relative contribution of ω3 polyunsaturated fatty acid (PUFA)-mediated alterations in the microbiota to metabolic parameter changes in mice. Four groups were compared: male fat-1 transgenic mice (with constitutive production of ω3 PUFAs) and male WT littermates fed either an obesogenic (high fat/high sucrose, HFHS) or a control diet. Unlike WT mice, HFHS-fed fat-1 mice were protected against obesity, glucose intolerance and hepatic steatosis. Unlike WT mice, fat-1 mice maintained a normal barrier function, resulting in a significantly lower metabolic endotoxemia. Fat-1 mice displayed greater phylogenic diversity in the cecum, and fecal microbiota transplantation from fat-1 to WT mice was able to reverse weight gain and to normalize glucose tolerance and intestinal permeability. We concluded that the ω3 fatty acid-mediated alteration of gut microbiota contributed to the prevention of metabolic syndrome in fat-1 mice. It occurred independently of changes in PUFA content of host tissues, and may represent a promising strategy to prevent metabolic disease and to preserve a lean phenotype.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01835624
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : mercredi 11 juillet 2018 - 15:22:45
Dernière modification le : mercredi 14 octobre 2020 - 03:55:49

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Célia Bidu, Quentin Escoula, Sandrine Bellenger, Aymé Spor, Maxime Galan, et al.. The Transplantation of ω3 PUFA-Altered Gut Microbiota of Fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders. Diabetes, American Diabetes Association, 2018, 67 (8), pp.1512-1523. ⟨10.2337/db17-1488⟩. ⟨hal-01835624⟩

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