The Transplantation of ω3 PUFA-Altered Gut Microbiota of Fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders

Célia Bidu; Quentin Escoula; Sandrine Bellenger; Aymé Spor; Maxime Galan; Audrey Geissler; André Bouchot; Dominique Dardevet; Béatrice Morio; Patrice Cani; Laurent Lagrost; Michel Narce; Jérôme Bellenger

doi:10.2337/db17-1488

Article dans une revue

The Transplantation of ω3 PUFA-Altered Gut Microbiota of Fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders

Célia Bidu ^{1, 2} Quentin Escoula ^{1, 2} Sandrine Bellenger ^{1, 2} Aymé Spor ³ Maxime Galan ⁴ Audrey Geissler ⁵ André Bouchot ⁵ Dominique Dardevet ⁶ Béatrice Morio ⁷ Patrice Cani ⁸ Laurent Lagrost ^{1, 2} Michel Narce ^{1, 2, *} Jérôme Bellenger ^{1, 2, *}

* Auteur correspondant

1 LNC - Lipides - Nutrition - Cancer [Dijon - U1231]

2 LabEx LipSTIC - Laboratoire d'Excellence : Lipoprotéines et Santé : prévention et Traitement des maladies Inflammatoires et du Cancer

3 Agroécologie [Dijon]

4 UMR CBGP - Centre de Biologie pour la Gestion des Populations

5 CellImaP - Plateforme d'Imagerie Cellulaire [Dijon]

6 UNH - Unité de Nutrition Humaine

7 CarMeN - Cardiovasculaire, métabolisme, diabétologie et nutrition

8 WELBIO - Walloon Excellence in Life sciences and BIOtechnology [Liège]

Abstract : Altering the gut microbiome may be beneficial to the host, and it recently arose as a promising strategy to manage obesity. Here, we investigated the relative contribution of ω3 polyunsaturated fatty acid (PUFA)-mediated alterations in the microbiota to metabolic parameter changes in mice. Four groups were compared: male fat-1 transgenic mice (with constitutive production of ω3 PUFAs) and male WT littermates fed either an obesogenic (high fat/high sucrose, HFHS) or a control diet. Unlike WT mice, HFHS-fed fat-1 mice were protected against obesity, glucose intolerance and hepatic steatosis. Unlike WT mice, fat-1 mice maintained a normal barrier function, resulting in a significantly lower metabolic endotoxemia. Fat-1 mice displayed greater phylogenic diversity in the cecum, and fecal microbiota transplantation from fat-1 to WT mice was able to reverse weight gain and to normalize glucose tolerance and intestinal permeability. We concluded that the ω3 fatty acid-mediated alteration of gut microbiota contributed to the prevention of metabolic syndrome in fat-1 mice. It occurred independently of changes in PUFA content of host tissues, and may represent a promising strategy to prevent metabolic disease and to preserve a lean phenotype.

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Médecine humaine et pathologie / Endocrinologie et métabolisme

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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01835624
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Soumis le : mercredi 11 juillet 2018 - 15:22:45
Dernière modification le : vendredi 21 janvier 2022 - 11:20:14

The Transplantation of ω3 PUFA-Altered Gut Microbiota of Fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders

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The Transplantation of ω3 PUFA-Altered Gut Microbiota of Fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders

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