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Brain-derived neurotrophic factor secreted by the cerebral endothelium: A new actor of brain function?

Abstract : Low cerebral levels of brain-derived neurotrophic factor (BDNF), which plays a critical role in many brain functions, have been implicated in neurodegenerative, neurological and psychiatric diseases. Thus, increasing BDNF levels in the brain is considered an attractive possibility for the prevention/treatment of various brain diseases. To date, BDNF-based therapies have largely focused on neurons. However, given the cross-talk between endothelial cells and neurons and recent evidence that BDNF expressed by the cerebral endothelium largely accounts for BDNF levels present in the brain, it is likely that BDNF-based therapies would be most effective if they also targeted the cerebral endothelium. In this review, we summarize the available knowledge about the biology and actions of BDNF derived from endothelial cells of the cerebral microvasculature and we emphasize the remaining gaps and shortcomings.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01857737
Contributeur : Caps - Université de Bourgogne <>
Soumis le : vendredi 17 août 2018 - 11:04:00
Dernière modification le : jeudi 17 septembre 2020 - 09:10:03

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Christine Marie, Martin Pedard, Aurore Quirie, Anne Tessier, Philippe Garnier, et al.. Brain-derived neurotrophic factor secreted by the cerebral endothelium: A new actor of brain function?. Journal of Cerebral Blood Flow and Metabolism, Nature Publishing Group, 2018, 38 (6), pp.935 - 949. ⟨10.1177/0271678X18766772⟩. ⟨hal-01857737⟩

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