Accéder directement au contenu Accéder directement à la navigation
Nouvelle interface
Article dans une revue

A New Method for Studying Licking Behavior Determinants in Rodents: Application to Diet-Induced Obese Mice

Aurélie Dastugue 1, 2 Jean-François Merlin 1, 2 Guillaume Maquart 1, 2 Arnaud Bernard 1, 2 Philippe Besnard 1, 2, * 
* Auteur correspondant
1 NUTOX - Equipe NuTox (LNC - U1231)
LNC - Lipides - Nutrition - Cancer [Dijon - U1231]
Abstract : Objective An original device for exploring taste‐guided reward behavior in rodents using a newly designed computer‐controlled liquid delivery system equipped with “lickometers” is described. Methods This octagonal shaped “gustometer” is composed of eight shutters that give random access during a few seconds to eight bottles delivering different liquid stimuli. This original design, which forces the animal to move for access to the drinking source, allows a simultaneous analysis of the licking behavior and motivation to drink. Determination of the sucrose licking behavior in diet‐induced obese mice was used to validate this method because nutritional obesity disturbs the sweet taste perception in rodents. Results A rise in sucrose response threshold and a decrease in the motivation to drink sweet solutions were found in mice fed the obesogenic diet. These data were highly reproducible among independent studies and corroborated the existence of functional links between diet‐induced obesity and gustation in rodents. Conclusions The FRM‐8 gustometer appears to be especially suitable for exploring determinants of behavioral outputs in response to oro‐sensory stimuli in the mouse. It also provides substantial information on the taste‐reward relationship, useful for better understanding the origin of gustatory efficiency or, conversely, dysfunction, as reported in nutritional obesity.
Type de document :
Article dans une revue
Liste complète des métadonnées
Contributeur : LNC - université de Bourgogne Connectez-vous pour contacter le contributeur
Soumis le : mercredi 7 novembre 2018 - 16:59:05
Dernière modification le : dimanche 26 juin 2022 - 01:54:58



Aurélie Dastugue, Jean-François Merlin, Guillaume Maquart, Arnaud Bernard, Philippe Besnard. A New Method for Studying Licking Behavior Determinants in Rodents: Application to Diet-Induced Obese Mice. Obesity, 2018, 26 (12), pp.1905-1914. ⟨10.1002/oby.22342⟩. ⟨hal-01915559⟩



Consultations de la notice