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Chapitre d'ouvrage
Transcriptional Programs Underlying Cd4 T Cell Differentiation and Functions.
Abstract : Understanding the basis of cellular differentiation is a fundamental issue in developmental biology but also for the comprehension of pathological processes. In fact, the palette of developmental decisions for naive CD4 T cells is a critical aspect of the development of appropriate immune responses which could control infectious processes or cancer growth. However, the current accumulation of data on CD4 T cells biology reveals a complex world with different helper populations. Naive CD4 T cells can differentiate into different subtypes in response to cytokine stimulation. This stimulation involves a complex transcriptional network implicating the activation of Signal Transducer and Activator of Transcription but also master regulator transcription factors allowing the functions of each helper T lymphocyte subtype. In this review, we will present an overview of the transcriptional regulation which controls process of helper T cells differentiation. We will focus on the role of initiator transcriptional factors and on master regulators but also on other nonspecific transcriptional factors which refine the T helper polarization to stabilize or modulate the differentiation program.
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01915895
Contributeur : Lnc - Université de Bourgogne Connectez-vous pour contacter le contributeur
Soumis le : jeudi 8 novembre 2018 - 10:01:08
Dernière modification le : jeudi 21 octobre 2021 - 05:20:47
Contributeur : Lnc - Université de Bourgogne Connectez-vous pour contacter le contributeur
Soumis le : jeudi 8 novembre 2018 - 10:01:08
Dernière modification le : jeudi 21 octobre 2021 - 05:20:47