Gastrointestinal pathogens in anti-FH antibody positive and negative Hemolytic Uremic Syndrome

Abstract : BACKGROUND: Prodromal symptoms are frequently reported in the atypical form of Hemolytic uremic syndrome (aHUS) suggesting implication of infectious triggers. Some pathogens may also play a role in the mechanisms of production of autoantibody directed against Factor H (FH), a complement regulator, leading to aHUS. METHODS: The presence of 15 gastrointestinal (GI) pathogens was investigated by using xTAG-based multiplex PCR techniques on stools collected at the acute phase in a cohort of Indian HUS children classified according to the presence or absence of anti-FH autoantibodies. RESULTS: Prevalence of pathogens in patients with anti-FH antibody (62.5%) was twice that in those without (31.5%). Different pathogens were detected, the most frequent being Clostridium difficile, Giardia intestinalis, Salmonella, Shigella, Rotavirus, Norovirus and Entamoeba histolytica. No stool was positive for Shigatoxin. CONCLUSION: This study reveals a higher prevalence of GI pathogens in anti-FH positive than in negative patients. No single pathogen was implicated exclusively in one form of HUS. These pathogens may play a role in the disease initiation by inducing complement activation or an autoimmune response.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01919340
Contributeur : Pam - Université de Bourgogne <>
Soumis le : lundi 12 novembre 2018 - 12:58:42
Dernière modification le : jeudi 13 juin 2019 - 11:14:03

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Shambhuprasad Togarsimalemath, Ali Si-Mohammed, Mamta Puraswani, Aarti Gupta, Astrid Vabret, et al.. Gastrointestinal pathogens in anti-FH antibody positive and negative Hemolytic Uremic Syndrome. Pediatric Research, Nature Publishing Group, 2018, 84 (1), pp.118 - 124. ⟨10.1038/s41390-018-0009-9⟩. ⟨hal-01919340⟩

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