Expert opinion on immunotherapy induced diabetes

Abstract : Immunotherapy often incurs side-effects, mainly involving the skin, digestive tract and endocrine system. The most frequent endocrine side-effects involve the pituitary and thyroid glands. Cases of insulin-dependent diabetes, whether autoimmune or not (type 1 or 1B) have been reported with PD-1/PD-L1 inhibitors, alone or in association with anti-CTLA-4 antibodies, and were systematically associated with sudden-onset insulinopenia, frequently leading to ketoacidosis or fulminant diabetes, requiring first-line insulin therapy. This adverse effect has not so far been reported with anti-CTLA-4 monotherapy.
Keywords : Diabetes
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01945900
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : mercredi 5 décembre 2018 - 15:57:05
Dernière modification le : vendredi 5 avril 2019 - 09:22:03

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Sarra Smati, Perrine Buffier, Benjamin Bouillet, Françoise Archambeaud, Bruno Vergès, et al.. Expert opinion on immunotherapy induced diabetes. Annales d'Endocrinologie, Elsevier Masson, 2018, 79 (5), pp.545-549. ⟨https://www.sciencedirect.com/science/article/pii/S0003426618311843⟩. ⟨10.1016/j.ando.2018.07.006⟩. ⟨hal-01945900⟩

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