First case of proven invasive pulmonary infection due to Trichoderma longibrachiatum in a neutropenic patient with acute leukemia

M. Sautour 1, 2 M.-L. Chretien 3 S. Valot 1 I. Lafon 3 L. Basmaciyan 1, 2 C. Legouge 3 T. Verrier 1 B. Gonssaud 1 H. Abou-Hanna 4 F. Dalle 2, 1, * D. Caillot 3
* Auteur correspondant
1 Laboratoire de parasitologie mycologie (CHU de Dijon)
2 PAM - Procédés Alimentaires et Microbiologiques [Dijon]
3 Service d'Hématologie Clinique (CHU de Dijon)
4 Service de chirurgie cardio-vasculaire et thoracique (CHU Dijon)
Abstract : Trichoderma species are saprophytic filamentous fungi that can be found all over the word. These fungi show increasing medical importance as opportunistic human pathogens, particularly in immunocompromised patients. Invasive infections due to Trichoderma are rare and definitive diagnosis is complex to achieve because of the lack of specific diagnosis tools. We report in this work the first proven case of invasive pulmonary infection due to T. longibrachiatum in a 69-year-old white male with hematologic malignancy. The patient was successfully treated initially with voriconazole alone followed by a combination of voriconazole and caspofungine.
Keywords : (1–3)-β-D-glucan Caspofungin-voriconazole combination therapy Invasive pulmonary infection Serum Aspergillus galactomannan Trichoderma longibrachiatum
Type de document :
Article dans une revue
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01961727
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : jeudi 20 décembre 2018 - 10:37:54
Dernière modification le : jeudi 20 décembre 2018 - 10:42:44

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M. Sautour, M.-L. Chretien, S. Valot, I. Lafon, L. Basmaciyan, et al.. First case of proven invasive pulmonary infection due to Trichoderma longibrachiatum in a neutropenic patient with acute leukemia. Journal de Mycologie Médicale, Elsevier Masson, 2018, 28 (4), pp.659-662. ⟨10.1016/j.mycmed.2018.10.001⟩. ⟨hal-01961727⟩

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