Nouvelles stratégies innovantes en immunothérapie

Abstract : Recent advances in immuno-oncology with the development of anti-PD1/PD-L1 antibodies are revolutionizing oncological management. Immuno-oncology I currently developing in most histological types of cancer. However, the rate of success of anti-PD1/PD-L1 antibodies in monotherapy is limited by a limited to a subpopulation of patients accounting for about 25-30 % of patients in most indications. The development of new strategies is based on this observation with the aim to predict response or enhancing response rate. Thus, we note the development of different strategies aimed at better selecting patients or combining inhibitory checkpoints with other therapies in order to increase their effectiveness. This review will study therapeutic test strategies to validate these new associations.
Type de document :
Article dans une revue
Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01972506
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : lundi 7 janvier 2019 - 17:14:17
Dernière modification le : jeudi 7 février 2019 - 14:28:41

Identifiants

Citation

François Ghiringhelli. Nouvelles stratégies innovantes en immunothérapie. Bulletin du Cancer, John Libbey Eurotext, 2018, 105, pp.S101-S112. ⟨https://www.sciencedirect.com/science/article/abs/pii/S0007455118303953?via%3Dihub⟩. ⟨10.1016/S0007-4551(18)30395-3⟩. ⟨hal-01972506⟩

Partager

Métriques

Consultations de la notice

22