Overweight is associated to a better prognosis in metastatic colorectal cancer: A pooled analysis of FFCD trials

Thomas Aparicio; Michel Ducreux; Roger Faroux; Emilie Barbier; Sylvain Manfredi; Thierry Lecomte; Pierre-Luc Etienne; Laurent Bedenne; Jaafar Bennouna; Jean-Marc Phélip; Eric François; Pierre Michel; Jean-Louis Legoux; Mohamed Gasmi; Gilles Breysacher; Philippe Rougier; Aimery de Gramont; Come Lepage; Olivier Bouché; Jean-François Seitz; - For Ffcd Investigators; Antoine Adenis; A Alessio; A Aouakli; A Azzedine; A Bedjaoui; A Bidault; A Blanchi; A Botton; A Cadier-Lagnes; A Fatisse; A Gagnaire; A Gilbert; A Gueye; A Hollebecque; A Lemaire; A Mahamat; A Marre; A Patenotte; A Rotenberg; A Roussel; A Thirot-Bidault; A Votte; A Weber; A Zaanan; Ac Dupont-Gossart; Al Villing; Am Queuniet; B Coudert; B Denis; B Garcia; B Lafforgue; B Landi; B Leduc; B Linot; B Paillot; B Rhein; B Winkfield; C Barberis; C Becht; C Belletier; C Berger; C Bineau; C Borel; C Brezault; C Buffet; C Cornila; C Couffon; C de la Fouchardière; C Giraud; C Lecaille; C Lepere; C Lobry; C Locher; C Lombard-Bohas; C Paoletti; C Platini; C Rebischung; C Sarda; C Vilain; C Briac-Levaché; D Auby; D Baudet-Klepping; D Bechade; D Besson; D Cleau; D Festin; D Gargot; D Genet; D Goldfain; D Luet; D Malka; D Peré-Vergé; D Pillon; D Sevin-Robiche; D Smith; D Soubrane; D Tougeron; D Zylberait; E Carola; E Cuillerier; E Dorval Danquechin; E Echinard; E Janssen; E Maillard; E Mitry; E Norguet-Monnereau; E Suc; E Terrebonne; E Zrihen; Ea Pariente; F Almaric; F Audemar; F Bonnetain; F Desseigne; F Dewaele; F Di Fiore; F Ghiringhelli; F Husseini; F Khemissa; F Kikolski; F Morvan; F Petit-Laurent; F Riot; F Subtil; F Zerouala-Boussaha; Fx Caroli-Bosc; G Boilleau-Jolimoy; G Bordes; G Cavaglione; G Coulanjon; G Deplanque; G Gatineau-Saillant; G Goujon; G Medinger; G Roquin; H Brixi-Benmansour; H Castanie; H Lacroix; H Maechel; H Perrier; H Salloum; H Senellart; I Baumgaertner; I Cumin; I Graber; I Trouilloud; J Boutin; J Butel; J Charneau; J Cretin; J Dauba; J Deguiral; J Egreteau; J Ezenfis; J Forestier; J Goineau; J Lacourt; J Lafon; J Martin; J Meunier; J Moreau; J Provencal; J Taieb; J Thaury; J Tuaillon; J Vergniol; J Villand; J Vincent; J Volet; Jb Bachet; Jc Barbare; Jc Souquet; Jd Grangé; Jf Dor; Jf Paitel; Jl Jouve; Jl Raoul; Jm Cheula; Jm Gornet; Jm Sabate; Jm Vantelon; Jn Vaillant; Jp Aucouturier; Jp Barbieux; Jp Herr; Jp Lafargue; Jp Lagasse; Jp Latrive; Jp Plachot; Jp Ramain; Jp Robin; Jp Spano; Jy Douillard; K Beerblock; K Bouhier-Leporrier; K Slimane Fawzi; L Cany; L Chone; L Dahan; L Gasnault; L Rob; L Wander; M Baconnier; M Ben Abdelghani; M Benchalal; M Blasquez; M Carreiro; M Charbit; M Combe; M Duluc; M Fayolle; M Gignoux; M Giovannini; M Glikmanas; M Mabro; M Mignot; M Mornet; M Mousseau; M Mozer; M Pauwels; M Pelletier; M Porneuf; M Ramdani; M Schnee; M Tissot; M Zawadi; Mc Clavero-Fabri; Mc Gouttebel; Mc Kaminsky; Mp Galais; N Abdelli; N Barrière; N Bouaria; N Bouarioua; N Delas; N Gérardin; N Hess-Laurens; N Stremsdoerfer; O Berthelet; O Boulat; O Capitain; O Favre; P Amoyal; P Bergerault; P Burtin; P Cassan; P Chatrenet; P Chiappa; P Claudé; P Couzigou; P Feydy; P Follana; P Geoffroy; P Godeau; P Hammel; P Laplaige; P Lehair; P Martin; P Novello; P Pantioni; P Pienkowski; P Pouderoux; P Prost; P Ruszniewski; P Souillac; P Texereau; P Thévenet; Pa Haineaux; R Benoit; R Coriat; R Lamy; R Mackiewicz; S Beorchia; S Chaussade; S Hiret; S Jacquot; S Lavau Denes; S Montembault; S Nahon; S Nasca; Son Nguyen; S Oddou-Lagraniere; S Pesque-Penaud; Sp Fratte; T Chatellier; T Mansourbakht; T Morin; T Walter; V Boige; V Bourgeois; V Derias; V Guérin-Meyer; V Hautefeuille; V Jestin Le Tallec; V Lorgis; V Quentin; V Sebbagh; V Veuillez; X Adhoute; X Coulaud; Y Becouarn; Y Coscas; Y Courouble; Y Le Bricquir; Y Molin; Y Rinaldi; Yh Lam; Z. Ladhib

doi:10.1016/j.ejca.2018.03.031

Article dans une revue

Overweight is associated to a better prognosis in metastatic colorectal cancer: A pooled analysis of FFCD trials

Thomas Aparicio ^{1, 2, *} Michel Ducreux ^{3, 4} Roger Faroux ⁵ Emilie Barbier ^{6, 7} Sylvain Manfredi ^{8, 7, 9} Thierry Lecomte ¹⁰ Pierre-Luc Etienne ¹¹ Laurent Bedenne ^{9, 8, 7} Jaafar Bennouna ¹² Jean-Marc Phélip ^{13, 14} Eric François ¹⁵ Pierre Michel ¹⁶ Jean-Louis Legoux ¹⁷ Mohamed Gasmi ¹⁸ Gilles Breysacher ¹⁹ Philippe Rougier ²⁰ Aimery de Gramont ²¹ Come Lepage ^{8, 7, 9} Olivier Bouché ²² Jean-François Seitz ²³ - For Ffcd Investigators Antoine Adenis A Alessio A Aouakli A Azzedine A Bedjaoui A Bidault A Blanchi A Botton A Cadier-Lagnes A Fatisse A Gagnaire A Gilbert A Gueye A Hollebecque A Lemaire A Mahamat A Marre A Patenotte A Rotenberg A Roussel A Thirot-Bidault A Votte A Weber A Zaanan Ac Dupont-Gossart Al Villing Am Queuniet B Coudert B Denis B Garcia B Lafforgue B Landi B Leduc B Linot B Paillot B Rhein B Winkfield C Barberis C Becht C Belletier C Berger C Bineau C Borel C Brezault C Buffet C Cornila C Couffon C de la Fouchardière C Giraud C Lecaille C Lepere C Lobry C Locher C Lombard-Bohas C Paoletti C Platini C Rebischung C Sarda C Vilain C Briac-Levaché D Auby D Baudet-Klepping D Bechade D Besson D Cleau D Festin D Gargot D Genet D Goldfain D Luet D Malka D Peré-Vergé D Pillon D Sevin-Robiche D Smith D Soubrane D Tougeron D Zylberait E Carola E Cuillerier E Dorval Danquechin E Echinard E Janssen E Maillard E Mitry E Norguet-Monnereau E Suc E Terrebonne E Zrihen Ea Pariente F Almaric F Audemar F Bonnetain F Desseigne F Dewaele F Di Fiore F Ghiringhelli F Husseini F Khemissa F Kikolski F Morvan F Petit-Laurent F Riot F Subtil F Zerouala-Boussaha Fx Caroli-Bosc G Boilleau-Jolimoy G Bordes G Cavaglione G Coulanjon G Deplanque G Gatineau-Saillant G Goujon G Medinger G Roquin H Brixi-Benmansour H Castanie H Lacroix H Maechel H Perrier H Salloum H Senellart I Baumgaertner I Cumin I Graber I Trouilloud J Boutin J Butel J Charneau J Cretin J Dauba J Deguiral J Egreteau J Ezenfis J Forestier J Goineau J Lacourt J Lafon J Martin J Meunier J Moreau J Provencal J Taieb J Thaury J Tuaillon J Vergniol J Villand J Vincent J Volet Jb Bachet Jc Barbare Jc Souquet Jd Grangé Jf Dor Jf Paitel Jl Jouve Jl Raoul Jm Cheula Jm Gornet Jm Sabate Jm Vantelon Jn Vaillant Jp Aucouturier Jp Barbieux Jp Herr Jp Lafargue Jp Lagasse Jp Latrive Jp Plachot Jp Ramain Jp Robin Jp Spano Jy Douillard K Beerblock K Bouhier-Leporrier K Slimane Fawzi L Cany L Chone L Dahan L Gasnault L Rob L Wander M Baconnier M Ben Abdelghani M Benchalal M Blasquez M Carreiro M Charbit M Combe M Duluc M Fayolle M Gignoux M Giovannini M Glikmanas M Mabro M Mignot M Mornet M Mousseau M Mozer M Pauwels M Pelletier M Porneuf M Ramdani M Schnee M Tissot M Zawadi Mc Clavero-Fabri Mc Gouttebel Mc Kaminsky Mp Galais N Abdelli N Barrière N Bouaria N Bouarioua N Delas N Gérardin N Hess-Laurens N Stremsdoerfer O Berthelet O Boulat O Capitain O Favre P Amoyal P Bergerault P Burtin P Cassan P Chatrenet P Chiappa P Claudé P Couzigou P Feydy P Follana P Geoffroy P Godeau P Hammel P Laplaige P Lehair P Martin P Novello P Pantioni P Pienkowski P Pouderoux P Prost P Ruszniewski P Souillac P Texereau P Thévenet Pa Haineaux R Benoit R Coriat R Lamy R Mackiewicz S Beorchia S Chaussade S Hiret S Jacquot S Lavau Denes S Montembault S Nahon S Nasca Son Nguyen S Oddou-Lagraniere S Pesque-Penaud Sp Fratte T Chatellier T Mansourbakht T Morin T Walter V Boige V Bourgeois V Derias V Guérin-Meyer V Hautefeuille V Jestin Le Tallec V Lorgis V Quentin V Sebbagh V Veuillez X Adhoute X Coulaud Y Becouarn Y Coscas Y Courouble Y Le Bricquir Y Molin Y Rinaldi Yh Lam Z. Ladhib

* Auteur correspondant

1 Service d'hépato-gastro-entérologie [Hôpital Saint-Louis]

2 USPC - Université Sorbonne Paris Cité

3 Université Paris-Saclay

4 Oncologie digestive

Département de médecine oncologique [Gustave Roussy]

5 Service de gastroentérologie (CHD Vendee - Hopital Les Oudairies, La Roche Sur Yon)

6 Fédération Francophone de la Cancérologie Digestive, FFCD

7 LNC - Lipides - Nutrition - Cancer [Dijon - U1231]

8 UBFC - Université Bourgogne Franche-Comté [COMUE]

9 Service d'Hépato-Gastro-Entérologie (CHU de Dijon)

10 Département d'hépato-gastro-entérologie [Hôpital Trousseau : CHRU Tours]

11 HPCA - Hôpital Privé des Côtes d'Armor

12 UNICANCER/ICO - Institut de Cancérologie de l'Ouest [Angers/Nantes]

13 Service de gastroentérologie [CHU Saint-Etienne]

14 Institut de Cancérologie de la Loire [Saint-Priest en Jarez]

15 UNICANCER/CAL - Centre de Lutte contre le Cancer Antoine Lacassagne [Nice]

16 Service d'Hépato-Gastroentérologie [CHU Rouen]

17 Service d'hépato-gastro-entérologie et oncologie digestive [CHR Orléans]

18 Service De Gastroenterologie, Hôpital Nord, Assistance Publique-Hôpitaux de Marseille

19 CH Colmar - Hôpital Louis Pasteur [Colmar]

20 Département d'hépato-gastro-entérologie [CHU Nantes]

21 Service d'oncologie [Institut Hospitalier Franco-Britannique : Levallois-Perret]

22 Département d'oncologie médicale (CHU Robert Debré, Reims)

23 Service d'oncologie digestive et hépato-gastro-entérologie [Hôpital de la Timone - APHM]

Abstract : BACKGROUND: Previous studies showed that high and low body mass index (BMI) was associated with worse prognosis in early-stage colorectal cancer (CRC), and low BMI was associated with worse prognosis in metastatic CRC (mCRC). We aimed to assess efficacy outcomes according to BMI. PATIENTS AND METHODS: A pooled analysis of individual data from 2085 patients enrolled in eight FFCD first-line mCRC trials from 1991 to 2013 was performed. Comparisons were made according to the BMI cut-off: Obese (BMI ≥30), overweight patients (BMI ≥ 25), normal BMI patients (BMI: 18.5-24) and thin patients (BMI <18.5). Interaction tests were performed between BMI effect and sex, age and the addition of antiangiogenics to chemotherapy. RESULTS: The rate of BMI ≥25 patients was 41.5%, ranging from 37.6% (1991-1999 period) to 41.5% (2000-2006 period) and 44.8% (2007-2013 period). Comparison of overweight patients versus normal BMI range patients revealed a significant improvement of median overall survival (OS) (18.5 versus 16.3 months, HR = 0.88 [0.80-0.98] p = 0.02) and objective response rate (ORR) (42% versus 36% OR = 1.23 [1.01-1.50] p = 0.04) but a comparable median progression-free survival (PFS) (7.8 versus 7.2 months, HR = 0.96 [0.87-1.05] p = 0.35). Subgroup analyses revealed that overweight was significantly associated with better OS in men. OS and PFS were significantly shorter in thin patients. CONCLUSION: Overweight patients had a prolonged OS compared with normal weight patients with mCRC. The association of overweight with better OS was only observed in men. The pejorative prognosis of BMI <18.5 was confirmed. Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved

Keywords : Prognostic factor Pooled analysis Bevacizumab Colorectal cancer Overweight

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Cancer

Sciences du Vivant [q-bio] / Médecine humaine et pathologie / Hépatologie et Gastroentérologie

Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01983308
Contributeur : Lnc - Université de Bourgogne Connectez-vous pour contacter le contributeur
Soumis le : mercredi 16 janvier 2019 - 12:41:38
Dernière modification le : mardi 11 janvier 2022 - 10:35:21

Overweight is associated to a better prognosis in metastatic colorectal cancer: A pooled analysis of FFCD trials

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