Cytotoxic glycosides from the roots of Weigela x “Bristol Ruby”

Duc Hung Nguyen (1, 2) , Anne-Claire Mitaine-Offer (1, 2) , Sveva Maroso (3) , Anna-Maria Papini (3) , Thomas Paululat (4) , Pierre-Simon Bellaye (5) , Bertrand Collin (6, 5) , Odile Chambin (7, 8, 2) , Marie-Aleth Lacaille-Dubois (1, 2)

1 PEPITE - Pathologies et épithéliums : prévention, innovation, traitements, évaluation (UR 4267)
2 UBFC - Université Bourgogne Franche-Comté [COMUE]
3 Department of Chemistry ''Ugo Schiff"
4 Naturwissenschaftlich-Technische Fakultät (Universität Siegen)
5 CGFL - Service de Médecine Nucléaire, Centre Georges-François Leclerc [Dijon]
6 ICMUB - Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon]
7 PAM - Procédés Alimentaires et Microbiologiques [Dijon]
8 PCAV - Physico-Chimie de l'Aliment et du Vin

Seven oleanane-type glycosides were extracted and isolated by various chromatographic methods from the roots of Weigela x "Bristol Ruby" (1-7), six previously undescribed (1-6) and a known one (7). Their structures were assigned by spectroscopic analysis mainly 2D NMR and mass spectrometry (ESIMS). Selected triterpenoid glycosides (1-3, 6, 7) displayed a good cytotoxic activity against a mouse colon cancer cell line CT26.

Mots clés: Caprifoliaceae; Cytotoxicity; NMR; Oleanolic acid glycosides; Weigela x “Bristol Ruby”

Domaines: Ingénierie des aliments

Duc Hung Nguyen, Anne-Claire Mitaine-Offer, Sveva Maroso, Anna-Maria Papini, Thomas Paululat, et al.. Cytotoxic glycosides from the roots of Weigela x “Bristol Ruby”. Fitoterapia, 2019, 137, pp.104242. ⟨10.1016/j.fitote.2019.104242⟩. ⟨hal-02172058⟩