Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib

Abstract : Approximately 1 to 3% of women have recurrent early miscarriages, defined as ≥3 pregnancy losses before 14 weeks of gestation. The immune deregulation and tolerance rupture could be the origin of these miscarriages in at least 30% of these women. Chronic intervillositis of unknown etiology (CIUE) is a rare placental lesion characterized by intrauterine deaths, growth restriction and high recurrence rate. In cases with recurrent obstetrical adverse events and intrauterine deaths, we previously reported the benefit of hydroxychloroquine combination to prednisone. Even few data raised the potential value of TNF antagonists in early recurrent miscarriages, these cases show its potential value in the setting of recurrent refractory chronic intervillositis and unexplained miscarriages.
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Soumis le : mercredi 10 juillet 2019 - 16:21:10
Dernière modification le : jeudi 11 juillet 2019 - 01:34:28

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Laure Ricard, Vincent Jachiet, Florent Malard, Yishan Ye, Nicolas Stocker, et al.. Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib. Annals of the Rheumatic Diseases, BMJ Publishing Group, 2019, 78 (4), pp.539-550. ⟨10.1136/annrheumdis-2018-214382⟩. ⟨hal-02178935⟩

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