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National sentinel surveillance of transmitted drug resistance in antiretroviral-naive chronically HIV-infected patients in France over a decade: 2001-2011

Diane Descamps 1 Lambert Assoumou 2 Marie-Laure Chaix 3 Antoine Chaillon 4 Sophie Pakianather 2 Alexis de Rougemont 5, 6, 7, 8 Alexandre Storto 1 Georges Santos Anne Krivine 9 Constance Delaugerre 10 Brigitte Montes 11 Jacques Izopet 12 Charlotte Charpentier 13 Marc Wirden 14 Anne Maillard 15 Laurence Morand-Joubert 16 Coralie Pallier 17 Jean-Christophe Plantier 18 Jérô Me Guinard Catherine Tamalet 19 Jacqueline Cottalorda 20 Anne-Geneviève Marcelin Delphine Desbois 21 Cécile Henquell 22 Vincent Calvez 23 Francoise Brun-Vézinet Bernard Masquelier Dominique Costagliola E. Lagier C. Roussel 24 H. Le Guillou-Guillemette 25 C. Alloui D. Bettinger 26 G. Anies S. Reigadas 27 P. Bellecave 27 P. Pinson-Recordon H. Fleury S. Vallet 28 M. Leroux 29 J. Dina 30 A. Vabret 31 J. Poveda A. Mirand 32 M. Bouvier-Alias 17 C. Noël 33 G. dos Santos S. Yerly C. Gaille W. Caveng S. Chapalay A. Calmy 34 A. Signori-Schmuck 35 P. Morand 36 L. Bocket L. Mouna S. Ranger-Rogez P. Andre 37 J. Tardy 38 M. Trabaud C. Delamare E. Schvoerer 39 E. André-Garnier 40 V. Ferre 41 A. Guigon J. Guinard 42 G. Peytavin 43 F. Brun-Vezinet S. Haim-Boukobza A. Roques C. Soulie 44 S. Lambert-Niclot 45 I. Malet S. Fourati 46 A.-G. Marcelin 45 P. Flandre 47 V. Schneider 48 C. Amiel 49 G. Giraudeau S. Fafi-Kremer 50 M. Schmitt S. Raymond 51 F. Barin 52 S. Marque Juillet
23 MMCS - Modélisation mathématique, calcul scientifique
ICJ - Institut Camille Jordan [Villeurbanne]
24 UR 0420 - Station de pathologie végétale
Laboratoire de pathologie forestière
51 MDN - Magnétisme et Diffusion Neutronique
MEM - Modélisation et Exploration des Matériaux : DRF/IRIG/MEM
Abstract : Objectives: As recommended by the French ANRS programme for the surveillance of HIV-1 resistance, we estimated the prevalence of transmitted drug resistance-associated mutations (RAMs) in antiretroviral-naive, chronically HIV-1-infected patients. Methods: RAMs were sought in samples from 661 newly diagnosed HIV-1-infected patients in 2010/11 at 36 HIVclinical care centres. Weighted analyses were used to derive representative estimates of the percentage of patients with RAMs. Results: At patient inclusion, the prevalence of virus with protease (PR) or reverse transcriptase (RT) RAMs was 9.0% (95% CI 6.8%-11.2%). No integrase RAMs were observed. The prevalences of protease inhibitor, nucleoside RT inhibitor and non-nucleoside RT inhibitor RAMs were 1.8%, 6.2% and 2.4%, respectively. Resistance to one, two and three classes of antiretroviral agent was observed in 7.9%, 0.9% and 0.2% of patients, respectively. The frequency of RAMs was higher in patients infected with B compared with non-B subtype virus (11.9% versus 5.1%, P¼0.003). Baseline characteristics (gender, age, country of transmission, CD4 cell count and viral load) were not associated with the prevalence of transmitted RAMs. However, men having sex with men (MSM) were more frequently infected with resistant virus than were other transmission groups (12.5% versus 5.8%, P¼0.003). Compared with the 2006/07 survey, the overall prevalence of resistance remained stable. However, a significant decrease in the frequency of virus with PR RAMs was observed in 2010/11 compared with the 2006/07 survey (1.8% versus 5.0%, P¼0.003). Conclusions: In France in 2010/11, the global prevalence of transmitted drug-resistant variants was 9.0%, and the prevalence was stable compared with the 2006/07 survey. MSM and B subtype-infected patients are the groups with a higher prevalence of drug resistance.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-02291004
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Dernière modification le : vendredi 20 novembre 2020 - 10:58:02
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Diane Descamps, Lambert Assoumou, Marie-Laure Chaix, Antoine Chaillon, Sophie Pakianather, et al.. National sentinel surveillance of transmitted drug resistance in antiretroviral-naive chronically HIV-infected patients in France over a decade: 2001-2011. Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2013, 68 (11), pp.2626-2631. ⟨10.1093/jac/dkt238⟩. ⟨hal-02291004⟩

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