Anti-Aging Effects of GDF11 on Skin

Luc Rochette (1) , Loubna Mazini (2) , Alexandre Meloux (1) , Marianne Zeller (1) , Yves Cottin (1) , Catherine Vergely (1) , Gabriel Malka (2)

1 PEC2 - Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon]
2 UM6P - Université Mohammed VI Polytechnique [Ben Guerir]

Human skin is composed of three layers: the epidermis, the dermis, and the hypodermis. The epidermis has four major cell layers made up of keratinocytes in varying stages of progressive differentiation. Skin aging is a multi-factorial process that affects every phase of its biology and function. The expression profiles of inflammation-related genes analyzed in resident immune cells demonstrated that these cells have a strong ability to regenerate adult skin stem cells and to produce endogenous substances such as growth differentiation factor 11 (GDF11). GDF11 appears to be the key to progenitor proliferation and/or differentiation. The preservation of youthful phenotypes has been tied to the presence of GDF11 in different human tissues, and, in the skin, this factor inhibits inflammatory responses. The protective role of GDF11 depends on a multi-factorial process implicating various types of skin cells such as keratinocytes, fibroblasts and inflammatory cells. GDF11 should be further studied for the purpose of developing novel therapies for the treatment of skin diseases.

Mots clés: skin aging; regeneration; growth factors; disease

Domaines: Dermatologie; Biochimie, Biologie Moléculaire

Luc Rochette, Loubna Mazini, Alexandre Meloux, Marianne Zeller, Yves Cottin, et al.. Anti-Aging Effects of GDF11 on Skin. International Journal of Molecular Sciences, 2020, 21 (7), pp.2598. ⟨10.3390/ijms21072598⟩. ⟨hal-03413453⟩