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Association Between Growth Differentiation Factor-15 and Heart Failure Complicating Acute Myocardial Infarction

Abstract : Background-Growth differentiation factor-15 (GDF15) is an emerging biomarker in cardiovascular diseases. We aimed to evaluate the association of GDF15 levels at admission with HF occurrence during hospitalization for acute myocardial infarction (AMI). Methods-Our prospective study included all patients admitted from June 2016 to February 2018 for type 1 AMI in the coronary care unit of the Dijon-Bourgogne University Hospital. In-hospital severe heart failure (HF) was defined as Killip class >2. Serum levels of GDF15 were obtained from blood samples were taken on admission. Results-Among the 284 AMI patients, median age was 67 years, and 27% were women. GDF15 levels were strongly correlated with age and positively correlated with most cardiovascular risk factors (hypertension and diabetes) and inflammation (CRP>3 mg/L). When compared with patients without HF (274/284), GDF15 in patients with inhospital HF (10/284) was more than two times
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-03413459
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Soumis le : mercredi 3 novembre 2021 - 18:02:21
Dernière modification le : jeudi 4 novembre 2021 - 03:07:40

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Alexandre Meloux, Luc Rochette, Maud Maza, Florence Bichat, Yves Cottin, et al.. Association Between Growth Differentiation Factor-15 and Heart Failure Complicating Acute Myocardial Infarction. Cardiology and Cardiovascular Medicine, Fortune Journals, 2020, 04 (6), pp.773-789. ⟨10.26502/fccm.92920174⟩. ⟨hal-03413459⟩

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