Association Between Growth Differentiation Factor-15 and Heart Failure Complicating Acute Myocardial Infarction

Alexandre Meloux (1) , Luc Rochette (1) , Maud Maza (2) , Florence Bichat (2) , Yves Cottin (1) , Marianne Zeller (1) , Catherine Vergely (1)

1 PEC2 - Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon]
2 CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand

Background-Growth differentiation factor-15 (GDF15) is an emerging biomarker in cardiovascular diseases. We aimed to evaluate the association of GDF15 levels at admission with HF occurrence during hospitalization for acute myocardial infarction (AMI). Methods-Our prospective study included all patients admitted from June 2016 to February 2018 for type 1 AMI in the coronary care unit of the Dijon-Bourgogne University Hospital. In-hospital severe heart failure (HF) was defined as Killip class >2. Serum levels of GDF15 were obtained from blood samples were taken on admission. Results-Among the 284 AMI patients, median age was 67 years, and 27% were women. GDF15 levels were strongly correlated with age and positively correlated with most cardiovascular risk factors (hypertension and diabetes) and inflammation (CRP>3 mg/L). When compared with patients without HF (274/284), GDF15 in patients with inhospital HF (10/284) was more than two times

Mots clés: Heart failure; GDF15; AMI; biomarker

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie; Cardiologie et système cardiovasculaire

Alexandre Meloux, Luc Rochette, Maud Maza, Florence Bichat, Yves Cottin, et al.. Association Between Growth Differentiation Factor-15 and Heart Failure Complicating Acute Myocardial Infarction. Cardiology and Cardiovascular Medicine, 2020, 04 (6), pp.773-789. ⟨10.26502/fccm.92920174⟩. ⟨hal-03413459⟩