Calorie Restriction in Adulthood Reduces Hepatic Disorders Induced by Transient Postnatal Overfeeding in Mice - Université de Bourgogne Accéder directement au contenu
Article Dans Une Revue Nutrients Année : 2019

Calorie Restriction in Adulthood Reduces Hepatic Disorders Induced by Transient Postnatal Overfeeding in Mice

Catherine Yzydorczyk
  • Fonction : Auteur
  • PersonId : 1115960
Hassib Chehade
  • Fonction : Auteur
  • PersonId : 1115961
Dolores Mosig
  • Fonction : Auteur
  • PersonId : 1115962
Jean Baptiste Armengaud
  • Fonction : Auteur
  • PersonId : 1115963
Thibaud Rolle
  • Fonction : Auteur
Anithan Krishnasamy
  • Fonction : Auteur
  • PersonId : 1115964
Eulalia Orozco
  • Fonction : Auteur
  • PersonId : 1115965
Benazir Siddeek
  • Fonction : Auteur
  • PersonId : 1115966
Christian Juvet
  • Fonction : Auteur
  • PersonId : 1115689
Umberto Simeoni
  • Fonction : Auteur

Résumé

Impaired early nutrition influences the risk of developing metabolic disorders in later life. We observed that transient postnatal overfeeding (OF) in mice induces long-term hepatic alterations, characterized by microsteatosis, fibrosis associated with oxidative stress (OS), and stress-induced premature senescence (SIPS). In this study, we investigated whether such changes can be reversed by moderate calorie restriction (CR). C57BL/6 male mice pups were maintained during lactation in litters adjusted to nine pups in the normal feeding (NF) group and three pups in the transient postnatal OF group. At six months of age, adult mice from the NF and OF groups were randomly assigned to an ad libitum diet or CR (daily energy supply reduced by 20%) for one month. In each group, at the age of seven months, analysis of liver structure, liver markers of OS (superoxide anion, antioxidant defenses), and SIPS (lipofuscin, p53, p21, p16, pRb/Rb, Acp53, sirtuin-1) were performed. CR in the OF group reduced microsteatosis, decreased levels of superoxide anion, and increased protein expression of catalase and superoxide dismutase. Moreover, CR decreased lipofuscin staining, p21, p53, Acp53, and p16 but increased pRb/Rb and sirtuin-1 protein expression. CR did not affect the NF group. These results suggest that CR reduces hepatic disorders induced by OF.
Fichier principal
Vignette du fichier
nutrients-11-02796-v2.pdf (5.59 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03416923 , version 1 (05-11-2021)

Identifiants

Citer

Catherine Yzydorczyk, Na Li, Eve Rigal, Hassib Chehade, Dolores Mosig, et al.. Calorie Restriction in Adulthood Reduces Hepatic Disorders Induced by Transient Postnatal Overfeeding in Mice. Nutrients, 2019, 11, ⟨10.3390/nu11112796⟩. ⟨hal-03416923⟩
9 Consultations
47 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More