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Cutting Edge: IL-1α Is a Crucial Danger Signal Triggering Acute Myocardial Inflammation during Myocardial Infarction

Abstract : Myocardial infarction (MI) induces a sterile inflammatory response which contributes to adverse cardiac remodeling. The initiating mechanisms of this response remain incompletely defined. We found that necrotic cardiomyocytes released a heat-labile pro-inflammatory signal activating MAP kinases and NF-κB in cardiac fibroblasts, with secondary production of cytokines. This response was abolished in Myd88 −/− fibroblasts, but was unaffected in nlrp3-deficient fibroblasts. Despite MyD88-dependency, the response was TLR-independent, as explored in TLR reporter cells, pointing to the implication of the IL-1 pathway. Indeed, necrotic cardiomyocytes released IL-1α, but not IL-1β, and the immune activation of cardiac fibroblasts was abrogated by an IL-1 receptor antagonist and an IL-1α blocking antibody. Moreover, immune responses triggered by necrotic Il1a −/− cardiomyocytes were markedly reduced. In vivo, mice exposed to MI released IL-1α in the plasma, and post-ischemic inflammation was attenuated in Il1a −/− mice. Thus, our findings identify IL-1α as a crucial early danger signal triggering post-MI inflammation.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-03434163
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Soumis le : jeudi 18 novembre 2021 - 10:33:27
Dernière modification le : vendredi 20 mai 2022 - 09:06:35
Archivage à long terme le : : samedi 19 février 2022 - 18:34:42

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Jérôme Lugrin, Roumen Parapanov, Nathalie Rosenblatt-Velin, Stéphanie Rignault-Clerc, François Feihl, et al.. Cutting Edge: IL-1α Is a Crucial Danger Signal Triggering Acute Myocardial Inflammation during Myocardial Infarction. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2016, 194, pp.499 - 503. ⟨10.4049/jimmunol.1401948⟩. ⟨hal-03434163⟩

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