Paradoxically, iron overload does not potentiate doxorubicin-induced cardiotoxicity in vitro in cardiomyocytes and in vivo in mice

Charles Guenancia (1) , Na Li (1) , Ahmed Habbout (1) , Olivier Hachet (1) , Eve Rigal (1) , Yves Cottin (1) , Patrick Dutartre (1) , Luc Rochette (1) , Catherine Vergely (1)

1 LPPCM - Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (U866, Lipides et nutrition, équipe 5)

This author takes the responsibility for all aspects of the reliability and freedom from bias of the data presented and their discussed interpretation.

Mots clés: Doxorubicin; iron overload; cardiotoxicity; oxidative stress; cell proliferation

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie; Cardiologie et système cardiovasculaire

Charles Guenancia, Na Li, Ahmed Habbout, Olivier Hachet, Eve Rigal, et al.. Paradoxically, iron overload does not potentiate doxorubicin-induced cardiotoxicity in vitro in cardiomyocytes and in vivo in mice. Toxicology and Applied Pharmacology, 2015, 284 (2), pp.152-162. ⟨10.1016/j.taap.2015.02.015⟩. ⟨hal-03434181⟩