Postnatal overfeeding in rats leads to moderate overweight and to cardiometabolic and oxidative alterations in adulthood

Ahmed Habbout (1) , Stephanie Delemasure (1) , Françoise Goirand (1) , Jean-Claude Guilland (1) , Franck Chabod (1) , Mourad Sediki (1) , Luc Rochette (2, 1) , Catherine Vergely (2, 1)

1 LPPCM - Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (U866, Lipides et nutrition, équipe 5)
2 PEC2 - Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon]

Mots clés: Postnatal overfeeding; heart; oxidative stress Ach; acetylcholine; ANOVA; analysis of variance; AU; arbitrary units; BMI; body mass index; BK; bradykinin; +dP/dt; left ventricular maximal pressure development; −dP/dt; left ventricular minimal pressure development; HR; heart rate; IU; international units; L; Langendorff mode; LDH; lactate dehydrogenase; LVDP; left ventricular developed pressure; LVEDP; left ventricular end-diastolic pressure; LVESP; left ventricular end-systolic pressure; MMP-2; matrix metallo-proteinase-2; NF; normal-fed; OF; overfeeding; SOD; superoxide dismutase; RLU; relative light units; ROOH; hydroperoxides; SNP; sodium nitroprussiate; W; working mode

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie; Cardiologie et système cardiovasculaire

Ahmed Habbout, Stephanie Delemasure, Françoise Goirand, Jean-Claude Guilland, Franck Chabod, et al.. Postnatal overfeeding in rats leads to moderate overweight and to cardiometabolic and oxidative alterations in adulthood. Biochimie, 2012, 94 (1), pp.117-124. ⟨10.1016/j.biochi.2011.09.023⟩. ⟨hal-03434326⟩