Conception and Evaluation of Fluorescent Phosphine‐Gold Complexes: From Synthesis to in vivo Investigations

Benjamin Rousselle (1) , Aurélie Massot (2) , Malorie Privat (1) , Lucile Dondaine (1) , Audrey Trommenschlager (1) , Florence Bouyer (3) , Jérôme Bayardon (1) , François Ghiringhelli (3) , Ali Bettaieb (2) , Christine Goze (1) , Catherine Paul (2) , Raluca Malacea-Kabbara (1) , Ewen Bodio (1)

1 ICMUB - Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon]
2 LIIC - Laboratoire d'Immunologie et d'Immunothérapie des cancers [Dijon]
3 LNC - Lipides - Nutrition - Cancer [Dijon - U1231]

A phosphine gold(I) and phosphine-phosphonium gold(I) complexes bearing a fluorescent coumarin moiety were synthesized and characterized. Both complexes displayed interesting photophysical properties: good molar absorption coefficient, good quantum yield of fluorescence, and ability to be tracked in vitro thanks to two-photon imaging. Their in vitro and in vivo biological properties were evaluated onto cancer cell lines both human and murine and into CT26 tumor-bearing BALB/c mice. They displayed moderate to strong antiproliferative properties and the phosphine-phosphonium gold(I) complex induced significant in vivo anti-cancer effect.

Domaines: Chimie de coordination; Chimie thérapeutique

Benjamin Rousselle, Aurélie Massot, Malorie Privat, Lucile Dondaine, Audrey Trommenschlager, et al.. Conception and Evaluation of Fluorescent Phosphine‐Gold Complexes: From Synthesis to in vivo Investigations. ChemMedChem, 2022, 17 (11), pp.e202100773. ⟨10.1002/cmdc.202100773⟩. ⟨hal-03806346⟩