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Effect of acute iron infusion on insulin secretion: A randomized, double-blind, placebo-controlled trial

Abstract : Background Chronic exposure to high iron levels increases diabetes risk partly by inducing oxidative stress, but the consequences of acute iron administration on beta cells are unknown. We tested whether the acute administration of iron for the correction of iron deficiency influenced insulin secretion and the production of reactive oxygen species. Methods Single-center, double-blinded, randomized controlled trial conducted between June 2017 and March 2020. 32 women aged 18 to 47 years, displaying symptomatic iron deficiency without anaemia, were recruited from a community setting and randomly allocated (1:1) to a single infusion of 1000 mg intravenous ferric carboxymaltose (iron) or saline (placebo). The primary outcome was the between group mean difference from baseline to day 28 in first and second phase insulin secretion, assessed by a two-step hyperglycaemic clamp. All analyses were performed by intention to treat. This trial was registered in ClinicalTrials.gov NCT03191201. Findings Iron infusion did not affect first and second phase insulin release. For first phase, the between group mean difference from baseline to day 28 was 0 mU £ 10 min/mL [95% CI,-22 to 22, P = 0.99]. For second phase, it was-5 mUx10min/mL [95% CI,-161 to 151; P = 0.95] at the first plateau of the clamp and-249 mUx10min/mL [95% CI,-635 to 137; P = 0.20] at the second plateau. Iron infusion increased serum ascorbyl/ascorbate ratio, a marker of plasma oxidative stress, at day 14, with restoration of normal ratio at day 28 relative to placebo. Finally, high-sensitive C-reactive protein levels remained similar among groups. Interpretation In iron deficient women without anaemia, intravenous administration of 1000 mg of iron in a single sitting did not impair glucose-induced insulin secretion despite a transient increase in the levels of circulating reactive oxygen species.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-03822541
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Soumis le : jeudi 20 octobre 2022 - 13:44:52
Dernière modification le : samedi 22 octobre 2022 - 03:23:42

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Fer Insuline Lausanne.pdf
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  • HAL Id : hal-03822541, version 1

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Evrim Jaccard, Alexandre Gouveia, Catherine Vergely, Laila Baratali, Marc Froissart, et al.. Effect of acute iron infusion on insulin secretion: A randomized, double-blind, placebo-controlled trial. EClinicalMedicine, 2022. ⟨hal-03822541⟩

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