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GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism

Abstract : Severe acute respiratory syndrome coronavirus 2 has caused a pandemic of respiratory and cardiovascular diseases. The receptor-binding domain on the surface subunit S1 is responsible for attachment of the virus to angiotensin-converting enzyme 2. The cytokine storm observed in COVID-19 patients contributes to the endothelial vascular dysfunction, which can lead to acute respiratory distress syndrome, multiorgan failure, alteration in iron homeostasis, and death. Growth and differentiation factor 15 (GDF15) plays a pivotal role in the development and progression of diseases. GDF15 appears to be a strong predictor of poor outcomes in critically COVID-19 patients and acts as "inflammatory-induced central mediator of tissue tolerance". The virus life cycle in host cell provides potential targets for drug therapy.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-03822708
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Soumis le : jeudi 20 octobre 2022 - 14:55:09
Dernière modification le : vendredi 21 octobre 2022 - 03:15:09

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TEM COVID Iron.pdf
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Luc Rochette, Marianne Zeller, Yves Cottin, Catherine Vergely. GDF15: an emerging modulator of immunity and a strategy in COVID-19 in association with iron metabolism. Trends in Endocrinology and Metabolism = Trends in Endocrinology & Metabolism , 2021, 32 (11), pp.875-889. ⟨10.1016/j.tem.2021.08.011⟩. ⟨hal-03822708⟩

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