Focal epilepsy disrupts spindle structure and function

Katharina Schiller , Tamir Avigdor (1) , Chifaou Abdallah (2) , Viviane Sziklas , Joelle Crane , Ambra Stefani (3) , Laure Peter-Derex (4, 5, 6) , Birgit Frauscher (7)

1 Montreal Neurological Institute and Hospital
2 Service de neurologie [CHRU Nancy]
3 IMU - Innsbruck Medical University = Medizinische Universität Innsbruck
4 HCL - Hospices Civils de Lyon
5 UCBL - Université Claude Bernard Lyon 1
6 CRNL - Centre de recherche en neurosciences de Lyon - Lyon Neuroscience Research Center
7 McGill University = Université McGill [Montréal, Canada]

Abstract Sleep spindles are the hallmark of N2 sleep and are attributed a key role in cognition. Little is known about the impact of epilepsy on sleep oscillations underlying sleep-related functions. This study assessed changes in the global spindle rate in patients with epilepsy, analysed the distribution of spindles in relation to the epileptic focus, and performed correlations with neurocognitive function. Twenty-one patients with drug-resistant focal epilepsy (12 females; mean age 32.6 ± 10.7 years [mean ± SD]) and 12 healthy controls (3 females; 24.5 ± 3.3 years) underwent combined whole-night high-density electroencephalography and polysomnography. Global spindle rates during N2 were lower in epilepsy patients compared to controls (mean = 5.78/min ± 0.72 vs. 6.49/min ± 0.71, p = 0.02, d = − 0.70). Within epilepsy patients, spindle rates were lower in the region of the epileptic focus compared to the contralateral region (median = 4.77/min [range 2.53–6.18] vs. 5.26/min [2.53–6.56], p = 0.02, rank biserial correlation RC = − 0.57). This decrease was driven by fast spindles (12–16 Hz) (1.50/min [0.62–4.08] vs. 1.65/min [0.51–4.28], p = 0.002, RC = − 0.76). The focal reduction in spindles was negatively correlated with two scales of attention (r = − 0.54, p = 0.01; r = − 0.51, p = 0.025). Patients with focal epilepsy show a reduction in global and local spindle rates dependent on the region of the epileptic focus. This may play a role in impaired cognitive functioning. Future work will show if the local reduction in spindles can be used as potential marker of the epileptic focus.

Domains: Life Sciences [q-bio]

Katharina Schiller, Tamir Avigdor, Chifaou Abdallah, Viviane Sziklas, Joelle Crane, et al.. Focal epilepsy disrupts spindle structure and function. Scientific Reports, 2022, 12 (1), pp.11137. ⟨10.1038/s41598-022-15147-0⟩. ⟨hal-04188553⟩