Role of biotransformation in the mutagenicity of Versicolorin A, a precursor of Aflatoxin B1

Carine Al-Ayoubi (1) , Justin Oules (2, 3) , Elodie Person (4) , Sandrine S. Bruel (4) , Alyssa Bouville (2, 5) , Philippe Pinton (1) , Emilien Jamin (5) , Isabelle P. Oswald (1) , Olivier Puel (2) , Ariane Vettorazzi , Laura Soler-Vasco (1)

1 ToxAlim-BioToMyc - Biosynthèse & Toxicité des Mycotoxines
2 ToxAlim - ToxAlim
3 MetaboHUB-MetaToul
4 ToxAlim-MeX - Métabolisme et Xénobiotiques
5 E20 - Metatoul AXIOM

Aflatoxin B1 (AFB1) exhibits the most severe toxicological effects of all known mycotoxins. Versicolorin A (VerA) is a precursor in the biosynthesis of AFB1. Both toxins are produced by the same aflatoxigenic species and can therefore co-contaminate food commodities. It is well established that the in vivo bioactivation of AFB1 into a highly reactive molecule is the key step in the mutagenic process. In contrast, much less is known about the toxicity of VerA and no information is available on its metabolization.

Domains: Vegetal toxicology and mycotoxicology; Analytical chemistry

Carine Al-Ayoubi, Justin Oules, Elodie Person, Sandrine S. Bruel, Alyssa Bouville, et al.. Role of biotransformation in the mutagenicity of Versicolorin A, a precursor of Aflatoxin B1. Mycotoxins and Phycotoxins Gordon Research Conference, Jun 2023, Boston (MA), United States. ⟨hal-04357518⟩