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Article Dans Une Revue Chaos, Solitons & Fractals Année : 2011

A hybrid stimulation strategy for suppression of spiral waves in cardiac tissue

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Résumé

Atrial fibrillation (AF) is the most common cardiac arrhythmia whose mechanisms are thought to be mainly due to the self perpetuation of spiral waves (SW). To date, available treatment strategies (antiarrhythmic drugs, radiofrequency ablation of the substrate, electrical cardioversion) to restore and to maintain a normal sinus rhythm have limitations and are associated with AF recurrences. The aim of this study was to assess a way of suppressing SW by applying multifocal electrical stimulations in a simulated cardiac tissue using a 2D FitzHugh-Nagumo model specially convenient for AF investigations. We identified stimulation parameters for successful termination of SW. However, SW reinduction, following the electrical stimuli, leads us to develop a hybrid strategy based on sodium channel modification for the simulated tissue.
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hal-00631743 , version 1 (13-10-2011)

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Binbin Xu, Sabir Jacquir, Gabriel Laurent, Jean-Marie Bilbault, Stéphane Binczak. A hybrid stimulation strategy for suppression of spiral waves in cardiac tissue. Chaos, Solitons & Fractals, 2011, 44 (8), pp.633-639. ⟨10.1016/j.chaos.2011.05.014⟩. ⟨hal-00631743⟩
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