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A hybrid stimulation strategy for suppression of spiral waves in cardiac tissue

Abstract : Atrial fibrillation (AF) is the most common cardiac arrhythmia whose mechanisms are thought to be mainly due to the self perpetuation of spiral waves (SW). To date, available treatment strategies (antiarrhythmic drugs, radiofrequency ablation of the substrate, electrical cardioversion) to restore and to maintain a normal sinus rhythm have limitations and are associated with AF recurrences. The aim of this study was to assess a way of suppressing SW by applying multifocal electrical stimulations in a simulated cardiac tissue using a 2D FitzHugh-Nagumo model specially convenient for AF investigations. We identified stimulation parameters for successful termination of SW. However, SW reinduction, following the electrical stimuli, leads us to develop a hybrid strategy based on sodium channel modification for the simulated tissue.
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Contributeur : Sabir Jacquir Connectez-vous pour contacter le contributeur
Soumis le : jeudi 13 octobre 2011 - 18:05:58
Dernière modification le : mardi 19 octobre 2021 - 11:45:32
Archivage à long terme le : : dimanche 4 décembre 2016 - 21:47:29


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Binbin Xu, Sabir Jacquir, Gabriel Laurent, Jean-Marie Bilbault, Stéphane Binczak. A hybrid stimulation strategy for suppression of spiral waves in cardiac tissue. Chaos, Solitons and Fractals, Elsevier, 2011, 44 (8), pp.633-639. ⟨10.1016/j.chaos.2011.05.014⟩. ⟨hal-00631743⟩



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