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A nanodosimetric model of radiation-induced clustered DNA damage yields

Abstract : We present a nanodosimetric model for predicting the yield of double strand breaks (DSBs) and non-DSB clustered damages induced in irradiated DNA. The model uses experimental ionization cluster size distributions measured in a gas model by an ion counting nanodosimeter or, alternatively, distributions simulated by a Monte Carlo track structure code developed to simulate the nanodosimeter. The model is based on a straightforward combinatorial approach translating ionizations, as measured or simulated in a sensitive gas volume, to lesions in a DNA segment of one-two helical turns considered equivalent to the sensitive volume of the nanodosimeter. The two model parameters, corresponding to the probability that a single ion detected by the nanodosimeter corresponds to a single strand break or a single lesion (strand break or base damage) in the equivalent DNA segment, were tuned by fitting the model-predicted yields to previously measured double-strand break and double-strand lesion yields in plasmid DNA irradiated with protons and helium nuclei. Model predictions were also compared to both yield data simulated by the PARTRAC code for protons of a wide range of different energies and experimental DSB and non-DSB clustered DNA damage yield data from the literature. The applicability and limitations of this model in predicting the LET dependence of clustered DNA damage yields are discussed.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-00680436
Contributeur : Sabine Julien <>
Soumis le : lundi 19 mars 2012 - 14:47:10
Dernière modification le : jeudi 31 octobre 2019 - 01:20:38

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  • HAL Id : hal-00680436, version 1

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G. Garty, R. Schulte, S. Shchemelinin, Corinne Leloup, G. Assaf, et al.. A nanodosimetric model of radiation-induced clustered DNA damage yields. Physics in Medicine and Biology, IOP Publishing, 2010, 55 (3), pp.761-81. ⟨hal-00680436⟩

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