Development of trackable metal-based drugs: new generation of therapeutic agents

Benoît Bertrand (1, 2) , Pierre-Emmanuel Doulain (1) , Christine Goze (1) , Ewen Bodio (1)

1 ICMUB - Institut de Chimie Moléculaire de l'Université de Bourgogne [Dijon]
2 School of Chemistry, University of East Anglia

In medicinal chemistry, the aim is not only to conceive ever more efficient molecules, but also to understand their mechanism of action. In very recent years, a new promising strategy was developed to tackle this issue: the conception of trackable therapeutic agents. Metal-based drugs are ideal to exploit this expanding area of research.

Mots clés: heterocyclic carbene complexes; potential anticancer agents; cancer-cells; in-vivo; organometallic compounds; platinum(ii) complexes; photodynamic therapy; cytotoxic properties; phosphine-porphyrin; theranostic agents

Domaines: Chimie; Chimie; Chimie inorganique

Benoît Bertrand, Pierre-Emmanuel Doulain, Christine Goze, Ewen Bodio. Development of trackable metal-based drugs: new generation of therapeutic agents. Dalton Transactions, 2016, 45 (33), pp.13005 - 13011. ⟨10.1039/c5dt04275e⟩. ⟨hal-01402883⟩