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Article dans une revue
DNA structure-specific sensitization of a metalloporphyrin leads to an efficient in vitro quadruplex detection molecular tool
Abstract : The search for convenient molecular probes for detecting DNA and RNA quadruplexes in vitro is marked by a rapid pace of progress, spurred on by the multiple roles these higher-order nucleic acid structures play in many genetic dysregulations. Here, we contribute to this search, reporting on a palladated porphyrin named Pd.TEGPy: its efficiency as quadruplex-selective fluorescent dye relies on a structural design that endows it with attractive supramolecular and electronic properties and makes it an efficient turn-on, quadruplex-selective fluorescent stain thanks to a DNA-mediated sensitization mechanism that ensures a high level of specificity.
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01427995
Contributeur : Icmub - Université de Bourgogne <>
Soumis le : vendredi 6 janvier 2017 - 11:29:49
Dernière modification le : vendredi 13 novembre 2020 - 09:08:03
Contributeur : Icmub - Université de Bourgogne <>
Soumis le : vendredi 6 janvier 2017 - 11:29:49
Dernière modification le : vendredi 13 novembre 2020 - 09:08:03