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DNA structure-specific sensitization of a metalloporphyrin leads to an efficient in vitro quadruplex detection molecular tool

Abstract : The search for convenient molecular probes for detecting DNA and RNA quadruplexes in vitro is marked by a rapid pace of progress, spurred on by the multiple roles these higher-order nucleic acid structures play in many genetic dysregulations. Here, we contribute to this search, reporting on a palladated porphyrin named Pd.TEGPy: its efficiency as quadruplex-selective fluorescent dye relies on a structural design that endows it with attractive supramolecular and electronic properties and makes it an efficient turn-on, quadruplex-selective fluorescent stain thanks to a DNA-mediated sensitization mechanism that ensures a high level of specificity.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01427995
Contributeur : Icmub - Université de Bourgogne <>
Soumis le : vendredi 6 janvier 2017 - 11:29:49
Dernière modification le : mardi 22 septembre 2020 - 03:55:51

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Pape Diaba Diabate, Aurélien Laguerre, Marc Pirrotta, Nicolas Desbois, Julien Boudon, et al.. DNA structure-specific sensitization of a metalloporphyrin leads to an efficient in vitro quadruplex detection molecular tool. New Journal of Chemistry, Royal Society of Chemistry, 2016, 40 (7), pp.5683 - 5689. ⟨10.1039/c6nj01012a⟩. ⟨hal-01427995⟩

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