Copy Number Variations in DCC/18q and ERBB2/17q are Associated with Disease-Free Survival in Microsatellite Stable Colon Cancer.

France Sefrioui 1, 2 France Vermeulin 3 France Blanchard 4 Caroline Chapusot 5 Ludivine Beaussire 1 Laura Armengol-Debeir 2 Richard Sesboué 1 Alice Gangloff 1, 2 Mohamed Hebbar 6 Marie-Christine Copin 7 Estelle Houivet 3 Lilian Schwarz 8 Florian Clatot 9 Jacques Tuech 10 Jacques Bénichou 3 Laurent Martin 5 Anne-Marie Bouvier 11 Jean-Christophe Sabourin Nasrin Sarafan-Vasseur 1 Thierry Frébourg 1 Côme Lepage 11 Pierre Michel 1, 2 Frédéric Di Fiore 1, 12, 2, *
* Auteur correspondant
1 GMFC - Génétique du cancer et des maladies neuropsychiatriques
2 Service d'Hépato-Gastroentérologie [Rouen]
3 Unité de biostatistiques [Rouen]
4 CHU Rouen
5 Service de Pathologie [CHU de Dijon]
6 Service d'oncologie médicale (CHRU Lille)
7 Service de pathologie [CHU Lille]
8 Département de chirurgie [Rouen]
9 CRLCC Henri Becquerel
10 Service de chirurgie digestive [Rouen]
11 Registre Bourguignon des Cancers Digestifs
LNC - Lipides - Nutrition - Cancer (U866), CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand
12 Service d'Oncologie Médicale
Abstract : We conducted a prospective study to assess the prognostic impact of selected copy number variations (CNVs) in stage II-III microsatellite stable (MSS) colon cancer. A total of 401 patients were included from 01/2004 to 01/2009. The CNVs in 8 selected target genes, DCC/18q, EGFR/7p, TP53/17p, BLK/8p, MYC/8q, APC/5q, ERBB2/17q, and STK6/20q, were detected using a quantitative multiplex polymerase chain reaction of short fluorescent fragment (QMPSF) method. The primary end-point was the impact of the CNVs on the 4-year disease-free survival (DFS). The recurrence rate at 4 years was 20.9%, corresponding to 14% stage II patients vs 31% stage III patients (p<0.0001). The 4-year DFS was significantly decreased in patients with a loss at DCC/18q (p=0.012) and a gain at ERBB2/17q (p=0.041). The multivariate analysis demonstrated that stage III, a loss at DCC/18q and a gain at ERBB2/17q were independent factors associated with DFS. A combination of DCC/18q and ERBB2/17q was also associated with relapse, with the hazard ratio increasing from 1 to 2.4 (95% confidence interval (CI), 1.5-4.1) and 3.1 (95% CI, 1.2-8.4) in the presence of 0, 1, or 2 alterations, respectively (p=0.0013). CNVs in DCC/18q and ERBB2/17q are significantly associated with DFS in stage II-III MSS colon cancer. This article is protected by copyright. All rights reserved.
Keywords : Disease-Free Survival Microstellite Stable Chromosomal instability Colon Cancer Copy Number Variation
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01447747
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : vendredi 27 janvier 2017 - 11:10:47
Dernière modification le : jeudi 14 novembre 2019 - 17:22:07

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UNIV-BOURGOGNE | COMUE-NORMANDIE | FNCLCC | BECQUEREL | LNC-UMR866 | ENSBANA | AGROSUP-DIJON | UNIROUEN

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France Sefrioui, France Vermeulin, France Blanchard, Caroline Chapusot, Ludivine Beaussire, et al.. Copy Number Variations in DCC/18q and ERBB2/17q are Associated with Disease-Free Survival in Microsatellite Stable Colon Cancer.. International Journal of Cancer, Wiley, 2016, 140 (7), pp.1653-1661 ⟨10.1002/ijc.30584⟩. ⟨hal-01447747⟩

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