Copy Number Variations in DCC/18q and ERBB2/17q are Associated with Disease-Free Survival in Microsatellite Stable Colon Cancer.

France Sefrioui; France Vermeulin; France Blanchard; Caroline Chapusot; Ludivine Beaussire; Laura Armengol-Debeir; Richard Sesboué; Alice Gangloff; Mohamed Hebbar; Marie-Christine Copin; Estelle Houivet; Lilian Schwarz; Florian Clatot; Jacques Tuech; Jacques Bénichou; Laurent Martin; Anne-Marie Bouvier; Jean-Christophe Sabourin; Nasrin Sarafan-Vasseur; Thierry Frébourg; Côme Lepage; Pierre Michel; Frédéric Di Fiore

Copy Number Variations in DCC/18q and ERBB2/17q are Associated with Disease-Free Survival in Microsatellite Stable Colon Cancer.

France Sefrioui ^{1, 2} France Vermeulin ³ France Blanchard ⁴ Caroline Chapusot ⁵ Ludivine Beaussire ¹ Laura Armengol-Debeir ² Richard Sesboué ¹ Alice Gangloff ^{1, 2} Mohamed Hebbar ⁶ Marie-Christine Copin ⁷ Estelle Houivet ³ Lilian Schwarz ⁸ Florian Clatot ⁹ Jacques Tuech ¹⁰ Jacques Bénichou ³ Laurent Martin ⁵ Anne-Marie Bouvier ¹¹ Jean-Christophe Sabourin Nasrin Sarafan-Vasseur ¹ Thierry Frébourg ¹ Côme Lepage ¹¹ Pierre Michel ^{1, 2} Frédéric Di Fiore ^{1, 12, 2, *}

* Auteur correspondant

1 GMFC - Génétique du cancer et des maladies neuropsychiatriques

2 Service d'Hépato-Gastroentérologie [Rouen]

3 Unité de biostatistiques [Rouen]

4 CHU Rouen

5 Service de Pathologie [CHU de Dijon]

6 Service d'oncologie médicale (CHRU Lille)

7 Service de pathologie [CHU Lille]

8 Département de chirurgie [Rouen]

9 CRLCC Henri Becquerel

10 Service de chirurgie digestive [Rouen]

11 Registre Bourguignon des Cancers Digestifs

LNC - Lipides - Nutrition - Cancer (U866), CHU Dijon - Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand

12 Service d'Oncologie Médicale

Abstract : We conducted a prospective study to assess the prognostic impact of selected copy number variations (CNVs) in stage II-III microsatellite stable (MSS) colon cancer. A total of 401 patients were included from 01/2004 to 01/2009. The CNVs in 8 selected target genes, DCC/18q, EGFR/7p, TP53/17p, BLK/8p, MYC/8q, APC/5q, ERBB2/17q, and STK6/20q, were detected using a quantitative multiplex polymerase chain reaction of short fluorescent fragment (QMPSF) method. The primary end-point was the impact of the CNVs on the 4-year disease-free survival (DFS). The recurrence rate at 4 years was 20.9%, corresponding to 14% stage II patients vs 31% stage III patients (p<0.0001). The 4-year DFS was significantly decreased in patients with a loss at DCC/18q (p=0.012) and a gain at ERBB2/17q (p=0.041). The multivariate analysis demonstrated that stage III, a loss at DCC/18q and a gain at ERBB2/17q were independent factors associated with DFS. A combination of DCC/18q and ERBB2/17q was also associated with relapse, with the hazard ratio increasing from 1 to 2.4 (95% confidence interval (CI), 1.5-4.1) and 3.1 (95% CI, 1.2-8.4) in the presence of 0, 1, or 2 alterations, respectively (p=0.0013). CNVs in DCC/18q and ERBB2/17q are significantly associated with DFS in stage II-III MSS colon cancer. This article is protected by copyright. All rights reserved.

Keywords : Disease-Free Survival Microstellite Stable Chromosomal instability Colon Cancer Copy Number Variation

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Cancer

Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01447747
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : vendredi 27 janvier 2017 - 11:10:47
Dernière modification le : jeudi 25 juillet 2019 - 14:24:51

Copy Number Variations in DCC/18q and ERBB2/17q are Associated with Disease-Free Survival in Microsatellite Stable Colon Cancer.

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Copy Number Variations in DCC/18q and ERBB2/17q are Associated with Disease-Free Survival in Microsatellite Stable Colon Cancer.

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