Abstract : The parasite Plasmodium vivax is the most widely distributed cause of recurring malaria. N-Myristoyltransferase (NMT), an enzyme that catalyses the covalent attachment of myristate to the N-terminal glycine of substrate proteins, has been described as a potential target for the treatment of this disease. Herein, we report the synthesis and the structure-guided optimization of a series of quinolines with balanced activity against both Plasmodium vivax and Plasmodium falciparum N-myristoyltransferase (NMT).
https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01496799
Contributeur : Icmub - Université de Bourgogne
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Soumis le : lundi 27 mars 2017 - 19:09:17
Dernière modification le : lundi 27 mars 2017 - 19:11:34
