Determinants of quality of life among long-term breast cancer survivors

Wai-On Chu 1, 2 Pegdwende Olivia Dialla 2, 1 Patrick Roignot 3 Marie-Christine Bone-Lepinoy 4 Marie-Laure Poillot 2, 1 Charles Coutant 5 Patrick Arveux 2, 1 Tienhan Sandrine Dabakuyo-Yonli 6, 2
1 Registre des Cancers du Sein et autres Cancers Gynécologiques de Côte d'Or - Breast and Gynaecologic Cancer Registry of Côte d’Or
CEP - Centre d'épidémiologie des populations
2 CEP - Centre d'épidémiologie des populations
3 Centre de pathologie [Dijon]
4 Centre d'oncologie et de radiothérapie du parc [Dijon]
5 Service de chirurgie [Centre Georges-François Leclerc]
6 Unité de biostatistiques [Centre Georges-François Leclerc]
Abstract : Purpose: To identify the impact of clinical and socio-economic determinants on quality of life (QoL) among breast cancer (BC) survivors 5 years after diagnosis. Methods: A cross-sectional survey was conducted in women diagnosed in 2007 for primary invasive non-metastatic BC and identified through the Côte d’Or BC registry. QoL was assessed with the Medical Outcomes Study 12-item Short Form Health Survey (SF-12), the European Organization for Research and Treatment of Cancer Quality of Life (EORTC-QLQ-C30) and the breast cancer (EORTC-QLQ-BR23) questionnaires. Social support was assessed with Sarason’s social support questionnaire, and deprivation was assessed by the EPICES questionnaire. Clinical variables were collected through the registry database. Determinants of QoL were identified using multivariable mixed model analysis for each SF-12 dimension. A sensitivity analysis was conducted with multiple imputations on missing data. Results: Overall, 188 patients on 319 patients (59 %) invited to participate to the survey completed the questionnaires. Five years after breast cancer diagnosis, the disease stages at diagnosis, as well as the treatment received, were not determinants of QoL. Only the age at diagnosis and comorbidities were found to be determinants of QoL. Conclusions: Five years after BC diagnosis, disease severity and the treatment received did not affect QoL.
Keywords : Breast cancer Determinant of quality of life Long-term survivor Social support Socio-economics factors
Type de document :
Article dans une revue
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01511602
Contributeur : Cep - Université de Bourgogne <>
Soumis le : vendredi 21 avril 2017 - 11:57:22
Dernière modification le : vendredi 8 juin 2018 - 14:50:17

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UNIV-BOURGOGNE | CGFL | FNCLCC

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Wai-On Chu, Pegdwende Olivia Dialla, Patrick Roignot, Marie-Christine Bone-Lepinoy, Marie-Laure Poillot, et al.. Determinants of quality of life among long-term breast cancer survivors. Quality of Life Research, Springer Verlag, 2016, 25 (8), pp.1981 - 1990. ⟨10.1007/s11136-016-1248-z⟩. ⟨hal-01511602⟩

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