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Article Dans Une Revue Molecular & Cellular Oncology Année : 2018

LPCAT2 controls chemoresistance in colorectal cancer

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Résumé

Lipid droplets (LD) are now-well recognized as playing a role in cancer progression, however their potential role in chemoresistance remains largely unknown, particularly in colorectal cancer (CRC). We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine acyltransferase 2 (LPCAT2) enzyme expression. We also showed that chemotherapy-induced LD accumulation counteracts intrinsic and extrinsic cancer cell death activation.

Dates et versions

hal-01820220 , version 1 (21-06-2018)

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Alexia Karen Cotte, Virginie Aires, François Ghiringhelli, Dominique Delmas. LPCAT2 controls chemoresistance in colorectal cancer. Molecular & Cellular Oncology, 2018, 5 (3), pp.e1448245. ⟨10.1080/23723556.2018.1448245⟩. ⟨hal-01820220⟩
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