LPCAT2 controls chemoresistance in colorectal cancer

Alexia Karen Cotte 1, 2, * Virginie Aires 1, 2 François Ghiringhelli 1, 2, 3 Dominique Delmas 1, 2
* Auteur correspondant
1 LNC - Lipides - Nutrition - Cancer [Dijon - U1231]
2 Equipe CADIR (LNC - U1231)
LNC - Lipides - Nutrition - Cancer [Dijon - U1231]
3 Département d'oncologie médicale [Centre Georges-François Leclerc]
Abstract : Lipid droplets (LD) are now-well recognized as playing a role in cancer progression, however their potential role in chemoresistance remains largely unknown, particularly in colorectal cancer (CRC). We recently highlighted that LD accumulate in CRC cells under the control of lysophosphatidylcholine acyltransferase 2 (LPCAT2) enzyme expression. We also showed that chemotherapy-induced LD accumulation counteracts intrinsic and extrinsic cancer cell death activation.
Keywords : colorectal cancer chemoresistance immunogenic cell death Lipid droplets LPCAT2
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Article dans une revue
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-01820220
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : jeudi 21 juin 2018 - 13:25:59
Dernière modification le : vendredi 15 mars 2019 - 13:51:47

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UNIV-BOURGOGNE | CGFL | FNCLCC | LNC-UMR866 | LNC-CADIR

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Alexia Karen Cotte, Virginie Aires, François Ghiringhelli, Dominique Delmas. LPCAT2 controls chemoresistance in colorectal cancer. Molecular & Cellular Oncology, Taylor et Francis, 2018, 5 (3), pp.e1448245. ⟨10.1080/23723556.2018.1448245⟩. ⟨hal-01820220⟩

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