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Longterm Risk of Solid Organ De Novo Malignancies After Liver Transplantation: A French National Study on 11,226 Patients

Olivier Sérée 1 Mario Altieri 1, 2 Elodie Guillaume 1 Rémy de Mil 1 Thierry Lobbedez 3 Philip Robinson 4 Philippe Segol 2 Ephrem Salamé 5 Armand Abergel 6, 7 Olivier Boillot 8 Filomena Conti 9 Olivier Chazouillères 10 Maryline Debette-Gratien 11, 12 Dominique Debray 13, 14 Géraldine Héry 15 Sébastien Dharancy 16 François Durand 17 Christophe Duvoux 18 Claire Francoz 17 Jean Gugenheim 19 Jean Hardwigsen 20 Pauline Houssel-Debry 21 Emmanuel Jacquemin 22 Nassim Kamar 23 Marianne Latournerie 24, 25 Pascal Lebray 9 Vincent Leroy 26 Alessandra Mazzola 9 Martine Neau-Cransac 27 Georges-Philippe Pageaux 28 Sylvie Radenne 4 Faouzi Saliba 29, 30 Didier Samuel 30, 29 Claire Vanlemmens 31 Marie-Lorraine Woehl-Jaegle 32 Guy Launoy 1 Jérôme Dumortier 8, *
* Auteur correspondant
10 Inserm UMR_S 938 - Pathologies biliaires, fibrose et cancer du foie
CR Saint-Antoine - Centre de Recherche Saint-Antoine, CHU Saint-Antoine [AP-HP]
24 Equipe EPICAD (LNC - U1231)
LNC - Lipides - Nutrition - Cancer [Dijon - U1231]
Abstract : De novo malignancies are one of the major late complications and causes of death after liver transplantation (LT). Using extensive data from the French national Agence de la Biomédecine database, the present study aimed to quantify the risk of solid organ de novo malignancies (excluding nonmelanoma skin cancers) after LT. The incidence of de novo malignancies among all LT patients between 1993 and 2012 was compared with that of the French population, standardized on age, sex, and calendar period (standardized incidence ratio; SIR). Among the 11,226 LT patients included in the study, 1200 de novo malignancies were diagnosed (10.7%). The risk of death was approximately 2 times higher in patients with de novo malignancy (48.8% versus 24.3%). The SIR for all de novo solid organ malignancies was 2.20 (95% confidence interval [CI], 2.08‐2.33). The risk was higher in men (SIR = 2.23; 95% CI, 2.09‐2.38) and in patients transplanted for alcoholic liver disease (ALD; SIR = 2.89; 95% CI, 2.68‐3.11). The cancers with the highest excess risk were laryngeal (SIR = 7.57; 95% CI, 5.97‐9.48), esophageal (SIR = 4.76; 95% CI, 3.56‐6.24), lung (SIR = 2.56; 95% CI, 2.21‐2.95), and lip‐mouth‐pharynx (SIR = 2.20; 95% CI, 1.72‐2.77). In conclusion, LT recipients have an increased risk of de novo solid organ malignancies, and this is strongly related to ALD as a primary indication for LT.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-02000599
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : mercredi 30 janvier 2019 - 16:35:51
Dernière modification le : jeudi 8 juillet 2021 - 03:52:00

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Olivier Sérée, Mario Altieri, Elodie Guillaume, Rémy de Mil, Thierry Lobbedez, et al.. Longterm Risk of Solid Organ De Novo Malignancies After Liver Transplantation: A French National Study on 11,226 Patients. Liver Transplantation, Wiley, 2018, 24 (10), pp.1425-1436. ⟨10.1002/lt.25310⟩. ⟨hal-02000599⟩

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