Longterm Risk of Solid Organ De Novo Malignancies After Liver Transplantation: A French National Study on 11,226 Patients

Olivier Sérée; Mario Altieri; Elodie Guillaume; Rémy de Mil; Thierry Lobbedez; Philip Robinson; Philippe Segol; Ephrem Salamé; Armand Abergel; Olivier Boillot; Filomena Conti; Olivier Chazouillères; Maryline Debette-Gratien; Dominique Debray; Géraldine Héry; Sébastien Dharancy; François Durand; Christophe Duvoux; Claire Francoz; Jean Gugenheim; Jean Hardwigsen; Pauline Houssel-Debry; Emmanuel Jacquemin; Nassim Kamar; Marianne Latournerie; Pascal Lebray; Vincent Leroy; Alessandra Mazzola; Martine Neau-Cransac; Georges-Philippe Pageaux; Sylvie Radenne; Faouzi Saliba; Didier Samuel; Claire Vanlemmens; Marie-Lorraine Woehl-Jaegle; Guy Launoy; Jérôme Dumortier

doi:10.1002/lt.25310

Article dans une revue

Longterm Risk of Solid Organ De Novo Malignancies After Liver Transplantation: A French National Study on 11,226 Patients

Olivier Sérée ¹ Mario Altieri ^{1, 2} Elodie Guillaume ¹ Rémy de Mil ¹ Thierry Lobbedez ³ Philip Robinson ⁴ Philippe Segol ² Ephrem Salamé ⁵ Armand Abergel ^{6, 7} Olivier Boillot ⁸ Filomena Conti ⁹ Olivier Chazouillères ¹⁰ Maryline Debette-Gratien ^{11, 12} Dominique Debray ^{13, 14} Géraldine Héry ¹⁵ Sébastien Dharancy ¹⁶ François Durand ¹⁷ Christophe Duvoux ¹⁸ Claire Francoz ¹⁷ Jean Gugenheim ¹⁹ Jean Hardwigsen ²⁰ Pauline Houssel-Debry ²¹ Emmanuel Jacquemin ²² Nassim Kamar ²³ Marianne Latournerie ^{24, 25} Pascal Lebray ⁹ Vincent Leroy ²⁶ Alessandra Mazzola ⁹ Martine Neau-Cransac ²⁷ Georges-Philippe Pageaux ²⁸ Sylvie Radenne ⁴ Faouzi Saliba ^{29, 30} Didier Samuel ^{30, 29} Claire Vanlemmens ³¹ Marie-Lorraine Woehl-Jaegle ³² Guy Launoy ¹ Jérôme Dumortier ^{8, *}

* Auteur correspondant

1 ANTICIPE - Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers

2 Hôpital Côte de Nacre [CHU Caen]

3 CHU Caen

4 HCL - Hospices Civils de Lyon

5 CHU Trousseau [Tours]

6 IP - Institut Pascal

7 CHU Estaing [Clermont-Ferrand]

8 Hôpital Edouard Herriot [CHU - HCL]

9 CHU Pitié-Salpêtrière [AP-HP]

10 Inserm UMR_S 938 - Pathologies biliaires, fibrose et cancer du foie

CR Saint-Antoine - Centre de Recherche Saint-Antoine, CHU Saint-Antoine [AP-HP]

11 Service d'Hépato-Gastro-Entérologie et Nutrition [CHU Limoges]

12 PIST - Pharmacologie des Immunosuppresseurs et de la Transplantation

13 CHU Necker - Enfants Malades [AP-HP]

14 AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP)

15 Service de pédiatrie multidisciplinaire [Hôpital de la Timone Enfants - APHM]

16 CHRU Lille - Centre Hospitalier Régional Universitaire [Lille]

17 CRI (UMR_S_1149 / ERL_8252 / U1149) - Centre de recherche sur l'Inflammation

18 CHU Henri Mondor

19 CHU Nice - Centre Hospitalier Universitaire de Nice

20 TIMONE - Hôpital de la Timone [CHU - APHM]

21 Hôpital Universitaire Pontchaillou

22 ICPH - Intéractions cellulaires et physiopathologie hépathique (Orsay, Essonne) UMRS 1174

23 Service de Néphrologie - Hypertension Artérielle Dialyse - Transplantation

24 Equipe EPICAD (LNC - U1231)

LNC - Lipides - Nutrition - Cancer [Dijon - U1231]

25 Service d'hépato-gastroentérologie et cancérologie digestive (CHU de Dijon)

26 IAB - Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble)

27 Hôpital Haut-Lévêque [CHU Bordeaux]

28 CHU Saint-Eloi

29 CHB - Centre hépato-biliaire

30 Physiopathologie et traitement des maladies du foie

31 Service d'hépatologie

32 Pôle des Pathologies Digestives Hépatiques et Transplantation [Hôpital Hautepierre-Strasbourg]

Abstract : De novo malignancies are one of the major late complications and causes of death after liver transplantation (LT). Using extensive data from the French national Agence de la Biomédecine database, the present study aimed to quantify the risk of solid organ de novo malignancies (excluding nonmelanoma skin cancers) after LT. The incidence of de novo malignancies among all LT patients between 1993 and 2012 was compared with that of the French population, standardized on age, sex, and calendar period (standardized incidence ratio; SIR). Among the 11,226 LT patients included in the study, 1200 de novo malignancies were diagnosed (10.7%). The risk of death was approximately 2 times higher in patients with de novo malignancy (48.8% versus 24.3%). The SIR for all de novo solid organ malignancies was 2.20 (95% confidence interval [CI], 2.08‐2.33). The risk was higher in men (SIR = 2.23; 95% CI, 2.09‐2.38) and in patients transplanted for alcoholic liver disease (ALD; SIR = 2.89; 95% CI, 2.68‐3.11). The cancers with the highest excess risk were laryngeal (SIR = 7.57; 95% CI, 5.97‐9.48), esophageal (SIR = 4.76; 95% CI, 3.56‐6.24), lung (SIR = 2.56; 95% CI, 2.21‐2.95), and lip‐mouth‐pharynx (SIR = 2.20; 95% CI, 1.72‐2.77). In conclusion, LT recipients have an increased risk of de novo solid organ malignancies, and this is strongly related to ALD as a primary indication for LT.

Keywords : Liver transplantation (LT)

Type de document :

Article dans une revue

Domaine :

Sciences du Vivant [q-bio] / Cancer

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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-02000599
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : mercredi 30 janvier 2019 - 16:35:51
Dernière modification le : jeudi 8 juillet 2021 - 03:52:00

Longterm Risk of Solid Organ De Novo Malignancies After Liver Transplantation: A French National Study on 11,226 Patients

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