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Longterm Risk of Solid Organ De Novo Malignancies After Liver Transplantation: A French National Study on 11,226 Patients

Olivier Sérée 1 Mario Altieri 1, 2 Elodie Guillaume 1 Rémy de Mil 1 Thierry Lobbedez 3 Philip Robinson Philippe Segol Ephrem Salamé Armand Abergel 4, 5 Olivier Boillot Filomena Conti Olivier Chazouillères 6 Maryline Debette-Gratien 7, 8 Dominique Debray 9, 10 Géraldine Héry 11 Sébastien Dharancy 12 François Durand 13 Christophe Duvoux 14 Claire Francoz 13 Jean Gugenheim Jean Hardwigsen Pauline Houssel-Debry Emmanuel Jacquemin 15 Nassim Kamar 16 Marianne Latournerie 17, 18 Pascal Lebray Vincent Leroy 19 Alessandra Mazzola Martine Neau-Cransac 20 Georges-Philippe Pageaux Sylvie Radenne 21 Faouzi Saliba 22, 23 Didier Samuel 23, 22 Claire Vanlemmens 24 Marie-Lorraine Woehl-Jaegle 25 Guy Launoy 1 Jérôme Dumortier *
* Auteur correspondant
6 Inserm UMR_S 938 - Pathologies biliaires, fibrose et cancer du foie
CHU Saint-Antoine [AP-HP], CR Saint-Antoine - Centre de Recherche Saint-Antoine
17 Equipe EPICAD (LNC - U1231)
LNC - Lipides - Nutrition - Cancer [Dijon - U1231]
Abstract : De novo malignancies are one of the major late complications and causes of death after liver transplantation (LT). Using extensive data from the French national Agence de la Biomédecine database, the present study aimed to quantify the risk of solid organ de novo malignancies (excluding nonmelanoma skin cancers) after LT. The incidence of de novo malignancies among all LT patients between 1993 and 2012 was compared with that of the French population, standardized on age, sex, and calendar period (standardized incidence ratio; SIR). Among the 11,226 LT patients included in the study, 1200 de novo malignancies were diagnosed (10.7%). The risk of death was approximately 2 times higher in patients with de novo malignancy (48.8% versus 24.3%). The SIR for all de novo solid organ malignancies was 2.20 (95% confidence interval [CI], 2.08‐2.33). The risk was higher in men (SIR = 2.23; 95% CI, 2.09‐2.38) and in patients transplanted for alcoholic liver disease (ALD; SIR = 2.89; 95% CI, 2.68‐3.11). The cancers with the highest excess risk were laryngeal (SIR = 7.57; 95% CI, 5.97‐9.48), esophageal (SIR = 4.76; 95% CI, 3.56‐6.24), lung (SIR = 2.56; 95% CI, 2.21‐2.95), and lip‐mouth‐pharynx (SIR = 2.20; 95% CI, 1.72‐2.77). In conclusion, LT recipients have an increased risk of de novo solid organ malignancies, and this is strongly related to ALD as a primary indication for LT.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-02000599
Contributeur : Lnc - Université de Bourgogne <>
Soumis le : mercredi 30 janvier 2019 - 16:35:51
Dernière modification le : mardi 6 octobre 2020 - 08:46:02

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Olivier Sérée, Mario Altieri, Elodie Guillaume, Rémy de Mil, Thierry Lobbedez, et al.. Longterm Risk of Solid Organ De Novo Malignancies After Liver Transplantation: A French National Study on 11,226 Patients. Liver Transplantation, Wiley, 2018, 24 (10), pp.1425-1436. ⟨10.1002/lt.25310⟩. ⟨hal-02000599⟩

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