Identification of Synaptic Integration Mode in CA3 Pyramidal Neuron Model

Jhunlyn Lorenzo; Roman Vuillaume; Steephane Binczak; Sabir Jacquir

Identification of Synaptic Integration Mode in CA3 Pyramidal Neuron Model

Jhunlyn Lorenzo ¹ Roman Vuillaume ¹ Steephane Binczak ¹ Sabir Jacquir ^{1, *}

* Auteur correspondant

1 Le2i - Laboratoire Electronique, Informatique et Image [UMR6303]

Abstract : A morphologically realistic and anisotropic model of CA3 pyramidal neuron was developed to determine the synaptic integration modes the neuron is able to perform. Linearity and nonlinearity were identified in different synaptic locations with varying active mechanisms such as the presence of ionic channels in the dendritic arbor and the types of receptors in the synapse. Quantification of synaptic integration was performed using paired-pulse stimulation protocol and subthreshold input/output (sI/O) transformation. Results show that the mode of synaptic integration is location-dependent while the linearity or nonlinearity in the integration is mainly influenced by the active channels and receptors in the neuron. A simple CA3 pyramidal neuron could therefore be considered as a two-layer network of neurons. Its computational power is enhanced by performing linear, sublinear and supralinear integration.

Keywords : Neurons Action potentials Shafts Neck Protocols Morphology Resistance biomembrane transport neurophysiology morphologically realistic model anisotropic model paired-pulse stimulation protocol active channels receptors simple CA3 pyramidal neuron supralinear integration CA3 pyramidal neuron model synaptic locations ionic channels dendritic arbor subthreshold input-output transformation two-layer network computational power sublinear integration linear integration bioelectric phenomena synaptic integration mode

Type de document :

Communication dans un congrès

Domaine :

Sciences du Vivant [q-bio] / Ingénierie biomédicale

Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-02152505
Contributeur : Caps - Université de Bourgogne <>
Soumis le : mardi 11 juin 2019 - 15:21:19
Dernière modification le : jeudi 13 juin 2019 - 01:31:32

Identification of Synaptic Integration Mode in CA3 Pyramidal Neuron Model

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Identification of Synaptic Integration Mode in CA3 Pyramidal Neuron Model

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