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A potential acetyltransferase involved in Leishmania major metacaspase-dependent cell death

Louise Basmaciyan 1 Nadine Azas 2, 3 Magali Casanova 2, 3, *
* Auteur correspondant
1 VAlMiS - Vin Aliment Microbiologie et Stress
PAM - Procédés Alimentaires et Microbiologiques, PAM - Procédés Alimentaires et Microbiologiques [Dijon]
Abstract : Currently, there is no satisfactory treatment for leishmaniases, owing to the cost, mode of administration, side effects and to the increasing emergence of drug resistance. As a consequence, the proteins involved in Leishmania apoptosis seem a target of choice for the development of new therapeutic tools against these neglected tropical diseases. Indeed, Leishmania cell death, while phenotypically similar to mammalian apoptosis, is very peculiar, involving no homologue of the key mammalian apoptotic proteins such as caspases and death receptors. Furthermore, very few proteins involved in Leishmania apoptosis have been identified.
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https://hal-univ-bourgogne.archives-ouvertes.fr/hal-02173356
Contributeur : Pam - Université de Bourgogne <>
Soumis le : jeudi 4 juillet 2019 - 14:15:02
Dernière modification le : vendredi 8 novembre 2019 - 15:14:04

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Louise Basmaciyan, Nadine Azas, Magali Casanova. A potential acetyltransferase involved in Leishmania major metacaspase-dependent cell death. Parasites and Vectors, BioMed Central, 2019, 12 (1), pp.266. ⟨10.1186/s13071-019-3526-4⟩. ⟨hal-02173356⟩

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