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Antiretroviral-naive and -treated HIV-1 patients can harbour more resistant viruses in CSF than in plasma

Cathia Soulié 1 Diane Descamps 2 Vé Ronique Schneider Mary-Anne Trabaud Laurence Morand-Joubert 3 Constance Delaugerre 4 Brigitte Montes 5 Francis Barin 6 Virginie Ferré 7 Anne Maillard 8 Sophie Vallet 9 Catherine Roussel 10 Lambert Assoumou 1 Vincent Calvez 11 Philippe Flandre 1 Anne-Geneviè Ve H. Jeulin 12 A. Guigon E. Lagier H. Le Guillou C. Alloui D. Bettinger 13 C. Pallier 14 H. Fleury S. Reigadas 15 P. Bellecave 15 P. Recordon-Pinson C. Payan 16 A. Vabret 17 C. Henquell 18 A. Mirand 19 M. Bouvier-Alias 20 Alexis de Rougemont 21, 22, 23, 24 G. dos Santos P. Morand 25 A. Signori-Schmuck 26 L. Bocket S. Rogez 27 P. Andre 28 J. Tardy 29 C. Tamalet 30 C. Delamare E. Schvoerer 12 E. André-Garnier 31 J. Cottalorda 32 J. Guinard A. Guiguon F. Brun-Vezinet C. Charpentier B. Visseaux G. Peytavin 33 A. Krivine 34 A. Si-Mohamed V. Avettand-Fenoel 35 A.-G. Marcelin 36 S. Lambert-Niclot 36 M. Wirden 36 M. Chaix C. Amiel 37 V. Schneider 38 G. Giraudeau V. Brodard J. Plantier C. Chaplain T. Bourlet 25 S. Fafi-Kremer 39 F. Stoll-Keller 40 M. Schmitt H. Barth 41 S. Yerly C. Poggi 42 Jacques Izopet 43 S. Raymond 44 A. Chaillon S. Marque-Juillet A. Roque-Afonso S. Haim-Boukobza Maxime Grude 36 D. Costagliola T. Allegre 45 J. Schmit J. Chennebault O. Bouchaud N. Magy-Bertrand 13 J. Delfraissy M. Dupon 46 P. Morlat D. Neau 47 S. Ansart 48 S. Jaffuel 49 R. Verdon 50 C. Jacomet Y. Levy S. Dominguez P. Chavanet 51 L. Piroth 52 A. Cabié 53 P. Leclercq F. Ajana A. Cheret P. Weinbreck L. Cotte 54 I. Poizot-Martin 55 I. Ravaud B. Christian F. Truchetet M. Grandidier J. Reynes 56 T. May 57 F. Goehringer 58 F. Raffi 59 P. Dellamonica 25 T. Prazuck 36 L. Hocqueloux P. Yeni R. Landman O. Launay 60 L. Weiss J. Viard C. Katlama 61 A. Simon Pascal Girard 62 J. Meynard J. Molina 63 G. Pialoux B. Hoen 64 M. Goeger-Sow I. Lamaury G. Beaucaire R. Jaussaud 65 C. Rouger C. Michelet F. Borsa-Lebas F. Caron 66 M. Khuong F. Lucht 67 D. Rey 68 A. Calmy 69 B. Marchou G. Gras A. Greder-Belan D. Vittecoq 70 E. Teicher 71
11 MMCS - Modélisation mathématique, calcul scientifique
ICJ - Institut Camille Jordan [Villeurbanne]
41 Environment and Sustainable Development Programme
European Commission - DG Research and Innovation
44 MDN - Magnétisme et Diffusion Neutronique
MEM - Modélisation et Exploration des Matériaux : DRF/IRIG/MEM
Abstract : Objectives: The neurological disorders in HIV-1-infected patients remain prevalent. The HIV-1 resistance in plasma and CSF was compared in patients with neurological disorders in a multicentre study. Methods: Blood and CSF samples were collected at time of neurological disorders for 244 patients. The viral loads were .50 copies/mL in both compartments and bulk genotypic tests were realized. Results: On 244 patients, 89 and 155 were antiretroviral (ARV) naive and ARV treated, respectively. In ARV-naive patients, detection of mutations in CSF and not in plasma were reported for the reverse transcriptase (RT) gene in 2/89 patients (2.2%) and for the protease gene in 1/89 patients (1.1%). In ARV-treated patients, 19/152 (12.5%) patients had HIV-1 mutations only in the CSF for the RT gene and 30/151 (19.8%) for the protease gene. Two mutations appeared statistically more prevalent in the CSF than in plasma: M41L (P ¼ 0.0455) and T215Y (P ¼0.0455). Conclusions: In most cases, resistance mutations were present and similar in both studied compartments. However, in 3.4% of ARV-naive and 8.8% of ARV-treated patients, the virus was more resistant in CSF than in plasma. These results support the need for genotypic resistance testing when lumbar puncture is performed.
Keywords : CSF resistance HIV ARV
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Cathia Soulié, Diane Descamps, Vé Ronique Schneider, Mary-Anne Trabaud, Laurence Morand-Joubert, et al.. Antiretroviral-naive and -treated HIV-1 patients can harbour more resistant viruses in CSF than in plasma. Journal of Antimicrobial Chemotherapy, Oxford University Press (OUP), 2015, 70 (2), pp.566-572. ⟨10.1093/jac/dku419⟩. ⟨hal-02291062⟩

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