Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

GDF15 and Cardiac Cells: Current Concepts and New Insights

Abstract : Growth and differentiation factor 15 (GDF15) belongs to the transforming growth factor-β (TGF-β) superfamily of proteins. Glial-derived neurotrophic factor (GDNF) family receptor α-like (GFRAL) is an endogenous receptor for GDF15 detected selectively in the brain. GDF15 is not normally expressed in the tissue but is prominently induced by “injury”. Serum levels of GDF15 are also increased by aging and in response to cellular stress and mitochondrial dysfunction. It acts as an inflammatory marker and plays a role in the pathogenesis of cardiovascular diseases, metabolic disorders, and neurodegenerative processes. Identified as a new heart-derived endocrine hormone that regulates body growth, GDF15 has a local cardioprotective role, presumably due to its autocrine/paracrine properties: antioxidative, anti-inflammatory, antiapoptotic. GDF15 expression is highly induced in cardiomyocytes after ischemia/reperfusion and in the heart within hours after myocardial infarction (MI). Recent studies show associations between GDF15, inflammation, and cardiac fibrosis during heart failure and MI. However, the reason for this increase in GDF15 production has not been clearly identified. Experimental and clinical studies support the potential use of GDF15 as a novel therapeutic target (1) by modulating metabolic activity and (2) promoting an adaptive angiogenesis and cardiac regenerative process during cardiovascular diseases. In this review, we comment on new aspects of the biology of GDF15 as a cardiac hormone and show that GDF15 may be a predictive biomarker of adverse cardiac events.
Liste complète des métadonnées

https://hal-univ-bourgogne.archives-ouvertes.fr/hal-03413423
Contributeur : Catherine Vergely Connectez-vous pour contacter le contributeur
Soumis le : mercredi 3 novembre 2021 - 17:42:33
Dernière modification le : jeudi 4 novembre 2021 - 03:07:40

Fichier

ijms-22-08889-v2.pdf
Fichiers éditeurs autorisés sur une archive ouverte

Identifiants

Collections

Citation

Luc Rochette, Geoffrey Dogon, Marianne Zeller, Yves Cottin, Catherine Vergely. GDF15 and Cardiac Cells: Current Concepts and New Insights. International Journal of Molecular Sciences, MDPI, 2021, 22 (16), pp.8889. ⟨10.3390/ijms22168889⟩. ⟨hal-03413423⟩

Partager

Métriques

Consultations de la notice

17

Téléchargements de fichiers

14