Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Clinical Science Année : 2015

Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse

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Résumé

In the present study, we report that genetic deletion of toll-like receptor 5 (TLR5) is associated with increased myocardial injury and dysfunction following ischaemia-reperfusion, by enhancing cardiac oxidative stress and p38 activation. TLR5 may thus convey cardioprotective signals during myocardial infarction (MI).
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hal-03434159 , version 1 (18-11-2021)

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Roumen Parapanov, Jérôme Lugrin, Nathalie Rosenblatt-Velin, François Feihl, Bernard Waeber, et al.. Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse. Clinical Science, 2015, 129 (2), pp.187-198. ⟨10.1042/CS20140444⟩. ⟨hal-03434159⟩
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