Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse

Roumen Parapanov , Jérôme Lugrin , Nathalie Rosenblatt-Velin , François Feihl , Bernard Waeber , Giuseppina Milano , Catherine Vergely (1, 2) , Na Li (1, 2) , Pal Pacher , Lucas Liaudet

1 PEC2 - Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon]
2 LPPCM - Laboratoire de Physiopathologie et Pharmacologie Cardio-Métaboliques (U866, Lipides et nutrition, équipe 5)

In the present study, we report that genetic deletion of toll-like receptor 5 (TLR5) is associated with increased myocardial injury and dysfunction following ischaemia-reperfusion, by enhancing cardiac oxidative stress and p38 activation. TLR5 may thus convey cardioprotective signals during myocardial infarction (MI).

Domaines: Sciences du Vivant [q-bio]; Médecine humaine et pathologie; Cardiologie et système cardiovasculaire

Roumen Parapanov, Jérôme Lugrin, Nathalie Rosenblatt-Velin, François Feihl, Bernard Waeber, et al.. Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse. Clinical Science, 2015, 129 (2), pp.187-198. ⟨10.1042/CS20140444⟩. ⟨hal-03434159⟩