Toll-like receptor 5 deficiency exacerbates cardiac injury and inflammation induced by myocardial ischaemia-reperfusion in the mouse

Abstract : In the present study, we report that genetic deletion of toll-like receptor 5 (TLR5) is associated with increased myocardial injury and dysfunction following ischaemia-reperfusion, by enhancing cardiac oxidative stress and p38 activation. TLR5 may thus convey cardioprotective signals during myocardial infarction (MI).