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Functional roles of GDF15 in modulating microenvironment to promote carcinogenesis

Abstract : Obesity and related metabolic dysregulation are risk factors for many types of cancer. The interactions between a developing tumor and its microenvironment are known to implicate a complex "crosstalk" among the factors produced by the population of cells. Among these factors, Growth and differentiation factor 15 (GDF15) has a functional role in cancer. GDF15 expression is induced in response to the conditions associated with cellular stress and diseases. The GDF15 receptor, a member of the glial-cell-derived neurotropic factor family (GDNF), is a GDNF family receptor α-like (GFRAL) protein. GDF15 induces pro-angiogenic effects in tumors. However, GDF15 could affect tumorigenesis both positively and negatively. With a better understanding of the upstream disease pathways reflected by GDF15, new treatment targets may emerge.
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Contributeur : Catherine Vergely Connectez-vous pour contacter le contributeur
Soumis le : lundi 24 octobre 2022 - 08:04:20
Dernière modification le : mardi 25 octobre 2022 - 03:14:52


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Luc Rochette, Alexandre Méloux, Marianne Zeller, Yves Cottin, Catherine Vergely. Functional roles of GDF15 in modulating microenvironment to promote carcinogenesis. Biochimica et Biophysica Acta - Molecular Basis of Disease, 2020, 1866 (8), ⟨10.1016/j.bbadis.2020.165798⟩. ⟨hal-03822258⟩



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