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Mitochondrial-derived peptides: New markers for cardiometabolic dysfunction

Abstract : Great attention is being paid to the evaluation of new markers in blood circulation for the estimation of tissue metabolism disturbance. This endogenous disturbance may contribute to the onset and progression of cardiometabolic disease. In addition to their role in energy production and metabolism, mitochondria play a main function in cellular mechanisms, including apoptosis, oxidative stress and calcium homeostasis. Mitochondria produce mitochondrial-derived peptides that mediate the transcriptional stress response by translocating into the nucleus and interacting with deoxyribonucleic acid. This class of peptides Abbreviations: ATP, adenosine triphosphate; CMD, coronary microvascular dysfunction; CNTFR, ciliary neuronotrophic factor receptor; DNA, deoxyribonucleic acid; ERK1/2, extracellular signal-regulated kinase 1/2; FPRL1, formyl peptide receptor-like 1; IGF-1, insulin-like growth factor-1; MDPs, mitochondrial-derived peptides; MOTS-c, mitochondrial open reading frame of the 12S ribosomal ribonucleic acid type c; mtDNA, mitochondrial deoxyribonucleic acid; ROS, reactive oxygen species; SHLP, small humanin-like peptide; STAT3, signal transducer and activator of transcription 3.
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Contributeur : Catherine Vergely Connectez-vous pour contacter le contributeur
Soumis le : lundi 24 octobre 2022 - 08:09:26
Dernière modification le : mardi 25 octobre 2022 - 03:14:52




Luc Rochette, Eve Rigal, Geoffrey Dogon, Gabriel Malka, Marianne Zeller, et al.. Mitochondrial-derived peptides: New markers for cardiometabolic dysfunction. Archives of cardiovascular diseases, 2021, 115, pp.48 - 56. ⟨10.1016/j.acvd.2021.10.013⟩. ⟨hal-03822684⟩



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