Tenectin is a novel alphaPS2betaPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila.

Stéphane Fraichard 1, * Anne-Laure Bougé 1 Timmy Kendall Isabelle Chauvel 1 Hervé Bouhin 1 Thomas A Bunch
* Auteur correspondant
1 CSGA - Centre des Sciences du Goût et de l'Alimentation [Dijon]
Abstract : Morphogenesis of the adult structures of holometabolous insects is regulated by ecdysteroids and juvenile hormones and involves cell-cell interactions mediated in part by the cell surface integrin receptors and their extracellular matrix (ECM) ligands. These adhesion molecules and their regulation by hormones are not well characterized. We describe the gene structure of a newly described ECM molecule, tenectin, and demonstrate that it is a hormonally regulated ECM protein required for proper morphogenesis of the adult wing and male genitalia. Tenectin's function as a new ligand of the PS2 integrins is demonstrated by both genetic interactions in the fly and by cell spreading and cell adhesion assays in cultured cells. Its interaction with the PS2 integrins is dependent on RGD and RGD-like motifs. Tenectin's function in looping morphogenesis in the development of the male genitalia led to experiments that demonstrate a role for PS integrins in the execution of left-right asymmetry.
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Contributeur : Sabine Julien <>
Soumis le : mercredi 5 décembre 2012 - 15:28:07
Dernière modification le : vendredi 8 juin 2018 - 14:50:15

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Stéphane Fraichard, Anne-Laure Bougé, Timmy Kendall, Isabelle Chauvel, Hervé Bouhin, et al.. Tenectin is a novel alphaPS2betaPS integrin ligand required for wing morphogenesis and male genital looping in Drosophila.. Developmental Biology, Elsevier, 2010, 340 (2), pp.504-17. ⟨10.1016/j.ydbio.2010.02.008⟩. ⟨hal-00761472⟩

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