Accéder directement au contenu Accéder directement à la navigation
Article dans une revue

High Fructose Diet inducing diabetes rapidly impacts olfactory epithelium and behavior in mice

Abstract : Type 2 Diabetes (T2D), a major public health issue reaching worldwide epidemic, has been correlated with lower olfactory abilities in humans. As olfaction represents a major component of feeding behavior, its alteration may have drastic consequences on feeding behaviors that may in turn aggravates T2D. In order to decipher the impact of T2D on the olfactory epithelium, we fed mice with a high fructose diet (HFruD) inducing early diabetic state in 4 to 8 weeks. After only 4 weeks of this diet, mice exhibited a dramatic decrease in olfactory behavioral capacities. Consistently, this decline in olfactory behavior was correlated to decreased electrophysiological responses of olfactory neurons recorded as a population and individually. Our results demonstrate that, in rodents, olfaction is modified by HFruD-induced diabetes. Functional, anatomical and behavioral changes occurred in the olfactory system at a very early stage of the disease.
Type de document :
Article dans une revue
Liste complète des métadonnées

Littérature citée [55 références]  Voir  Masquer  Télécharger
Contributeur : CSGA - université de Bourgogne Connectez-vous pour contacter le contributeur
Soumis le : mardi 26 septembre 2017 - 21:32:14
Dernière modification le : vendredi 11 février 2022 - 15:40:04

Accord explicite pour ce dépôt



Sébastien Rivière, Vanessa Soubeyre, David D. Jarriault, Adrien Molinas, Elise Léger-Charnay, et al.. High Fructose Diet inducing diabetes rapidly impacts olfactory epithelium and behavior in mice. Scientific Reports, Nature Publishing Group, 2016, 6, pp.34011. ⟨10.1038/srep34011⟩. ⟨hal-01397534⟩



Consultations de la notice


Téléchargements de fichiers