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Ophthalmic epidemiology in Europe: the “European Eye Epidemiology” (E3) consortium

Cécile Delcourt * Jean-François Korobelnik 1 Gabriëlle H. S. Buitendijk 2 Paul J. Foster 3 Christopher J. Hammond 4 Stefano Piermarocchi 5 Tunde Peto 6 Nomdo Jansonius 7 Alireza Mirshahi 8 Ruth E. Hogg 9 Lionel Brétillon 10 Fotis Topouzis 11 Gabor Deak 12 Eric H. Souied 13 Catherine Creuzot-Garcher 10, 14 José Sahel 15, 16 Vincent Daien 17, 18 Terho Lehtimäki 19 Hans-Werner Hense Elena Prokofyeva 20 Konrad Oexle 21 Jugnoo S. Rahi 22 Phillippa M. Cumberland 22 Geir Bertelsen 23 Carel Hoyng 24 Arthur Bergen Rufino Silva 25 Sebastian Wolf 26 Andrew Lotery 27 Usha Chakravarthy 9 Astrid Fletcher 28 Caroline C. W. Klaver 2 
Abstract : The European Eye Epidemiology (E3) consortium is a recently formed consortium of 29 groups from 12 European countries. It already comprises 21 population-based studies and 20 other studies (case-control, cases only, randomized trials), providing ophthalmological data on approximately 170,000 European participants. The aim of the consortium is to promote and sustain collaboration and sharing of data and knowledge in the field of ophthalmic epidemiology in Europe, with particular focus on the harmonization of methods for future research, estimation and projection of frequency and impact of visual outcomes in European populations (including temporal trends and European subregions), identification of risk factors and pathways for eye diseases (lifestyle, vascular and metabolic factors, genetics, epigenetics and biomarkers) and development and validation of prediction models for eye diseases. Coordinating these existing data will allow a detailed study of the risk factors and consequences of eye diseases and visual impairment, including study of international geographical variation which is not possible in individual studies. It is expected that collaborative work on these existing data will provide additional knowledge, despite the fact that the risk factors and the methods for collecting them differ somewhat among the participating studies. Most studies also include biobanks of various biological samples, which will enable identification of biomarkers to detect and predict occurrence and progression of eye diseases. This article outlines the rationale of the consortium, its design and presents a summary of the methodology.
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Soumis le : vendredi 18 novembre 2016 - 13:11:39
Dernière modification le : vendredi 25 novembre 2022 - 19:07:32

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Cécile Delcourt, Jean-François Korobelnik, Gabriëlle H. S. Buitendijk, Paul J. Foster, Christopher J. Hammond, et al.. Ophthalmic epidemiology in Europe: the “European Eye Epidemiology” (E3) consortium. European Journal of Epidemiology, 2016, 31 (2), pp.197 - 210. ⟨10.1007/s10654-015-0098-2⟩. ⟨hal-01399128⟩



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