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Article Dans Une Revue European Journal of Organic Chemistry Année : 2018

Efficient Synthesis of Multifunctional Chelating Agents Based on Tetraazacycloalkanes

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Résumé

An efficient route has been developed for the synthesis of multifunctional tetraazacycloalkanes (in particular 1,4,7,10-tetraazacyclotridecane) incorporating an aminomethyl pendant arm on the carbon skeleton. Starting from the appropriate C-functionalized bisaminal-protected intermediate, the target macrocycles were easily obtained by means of a step-by-step introduction of the desired functional groups onto the free primary amine group, followed by deprotection of the bisaminal intermediates. This straightforward and versatile synthetic approach paves the way for the design of a new family of multifunctional chelators.
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Dates et versions

hal-01908764 , version 1 (30-10-2018)

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Nicolas Sok, Claire Bernhard, Pauline Désogère, Christine Goze, Yoann Rousselin, et al.. Efficient Synthesis of Multifunctional Chelating Agents Based on Tetraazacycloalkanes. European Journal of Organic Chemistry, 2018, 2018 (34), pp.4762 - 4768. ⟨10.1002/ejoc.201800801⟩. ⟨hal-01908764⟩
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