Efficient Synthesis of Multifunctional Chelating Agents Based on Tetraazacycloalkanes

Abstract : An efficient route has been developed for the synthesis of multifunctional tetraazacycloalkanes (in particular 1,4,7,10-tetraazacyclotridecane) incorporating an aminomethyl pendant arm on the carbon skeleton. Starting from the appropriate C-functionalized bisaminal-protected intermediate, the target macrocycles were easily obtained by means of a step-by-step introduction of the desired functional groups onto the free primary amine group, followed by deprotection of the bisaminal intermediates. This straightforward and versatile synthetic approach paves the way for the design of a new family of multifunctional chelators.
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Contributeur : Pam - Université de Bourgogne <>
Soumis le : mardi 30 octobre 2018 - 14:50:55
Dernière modification le : mercredi 19 décembre 2018 - 15:02:09



Nicolas Sok, Claire Bernhard, Pauline Désogère, Christine Goze, Yoann Rousselin, et al.. Efficient Synthesis of Multifunctional Chelating Agents Based on Tetraazacycloalkanes. European Journal of Organic Chemistry, Wiley-VCH Verlag, 2018, 2018 (34), pp.4762 - 4768. ⟨10.1002/ejoc.201800801⟩. ⟨hal-01908764⟩



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