“Pro-youthful” factors in the “labyrinth” of cardiac rejuvenation

Luc Rochette (1) , Catherine Vergely (1)

1 PEC2 - Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon]

The mechanisms of aging and senescence include various endogenous and exogenous factors. Among cardiovascular diseases, heart failure is a typical age-related disease. New strategies to restore cardiomyocyte cells have been reported: endogenous substances that can regenerate the heart's cardiomyocytes have been described: follistatin like 1 (FSTL1), growth-differentiation factor 11 (GDF11) and insulin-like growth factor 1 (IGF-I). Manipulation of the different anti and pro-pathways is essential to discover new approaches to regenerative therapies.

Domaines: Cardiologie et système cardiovasculaire

Luc Rochette, Catherine Vergely. “Pro-youthful” factors in the “labyrinth” of cardiac rejuvenation. Experimental Gerontology, 2016, 83, pp.1-5. ⟨10.1016/j.exger.2016.07.004⟩. ⟨hal-03433350⟩