In-vivo and in-vitro impact of high-dose rate radiotherapy using flattening-filter-free beams on the anti-tumor immune response

P.A. Laurent (1) , A. Kownacka (1) , R. Boidot (1) , C. Richard (1, 2) , E. Limagne (2, 1) , V. Morgand (3) , L. Froidurot (3) , C. Bonin (1) , L. Aubignac (1) , F. Ghiringhelli (4, 2) , G. Créhange (5, 4) , C. Mirjolet (4, 2)

1 UNICANCER/CRLCC-CGFL - Centre Régional de Lutte contre le cancer Georges-François Leclerc [Dijon]
2 LNC - Lipides - Nutrition - Cancer [Dijon - U1231]
3 Service de radiologie [Centre Georges-François Leclerc]
4 Département d'oncologie médicale [Centre Georges-François Leclerc]
5 Equipe IFTIM [ImViA - EA7535]

Highlights • Effect of RT dose rate modulation on immune response has never been evaluated. • Preclinical study using FFF RT technique in vivo and in vitro. • RT dose rate did not influence radio-immune response parameters. • We may modulate RT dose rate in association with immunotherapy without efficacy modification.

Mots clés: Radio-induced immune response; Dose rate modulation; Flattening filter free

Domaines: Sciences du Vivant [q-bio]

P.A. Laurent, A. Kownacka, R. Boidot, C. Richard, E. Limagne, et al.. In-vivo and in-vitro impact of high-dose rate radiotherapy using flattening-filter-free beams on the anti-tumor immune response. Clinical and Translational Radiation Oncology, 2020, 24 (1), pp.116-122. ⟨10.1016/j.ctro.2020.07.004⟩. ⟨hal-03612950⟩